Protein robustness promotes evolutionary innovations on large evolutionary time-scales.

Proceedings. Biological Sciences
Evandro Ferrada, Andreas Wagner

Abstract

Recent laboratory experiments suggest that a molecule's ability to evolve neutrally is important for its ability to generate evolutionary innovations. In contrast to laboratory experiments, life unfolds on time-scales of billions of years. Here, we ask whether a molecule's ability to evolve neutrally-a measure of its robustness-facilitates evolutionary innovation also on these large time-scales. To this end, we use protein designability, the number of sequences that can adopt a given protein structure, as an estimate of the structure's ability to evolve neutrally. Based on two complementary measures of functional diversity-catalytic diversity and molecular functional diversity in gene ontology-we show that more robust proteins have a greater capacity to produce functional innovations. Significant associations among structural designability, folding rate and intrinsic disorder also exist, underlining the complex relationship of the structural factors that affect protein evolution.

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Citations

Jul 14, 2010·Genome Biology and Evolution·Kate E RidoutDmitry A Filatov
May 24, 2011·Genome Biology and Evolution·Mary M Rorick, Günter P Wagner
Jun 11, 2010·Journal of the Royal Society, Interface·Karthik Raman, Andreas Wagner
Jan 6, 2012·Proceedings. Biological Sciences·Andreas Wagner
Apr 11, 2009·Science·Nobuhiko Tokuriki, Dan S Tawfik
Feb 5, 2013·Artificial Life·Joshua L PayneAndreas Wagner
Jan 8, 2011·BMC Evolutionary Biology·Carlos Espinosa-SotoAndreas Wagner
Mar 10, 2011·BMC Systems Biology·João F Matias Rodrigues, Andreas Wagner
Jun 14, 2012·PLoS Computational Biology·Macarena Toll-RieraJoshua B Plotkin
Jul 5, 2012·PLoS Computational Biology·Claus O Wilke
Aug 6, 2011·PloS One·Rosa TarríoFrancisco Rodríguez-Trelles
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Aug 26, 2014·Trends in Plant Science·Zebulun W ArendseeEve Syrkin Wurtele
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Dec 10, 2016·PLoS Computational Biology·György Abrusán, Joseph A Marsh
Dec 12, 2017·Genome Biology and Evolution·Xinzhu Wei, Jianzhi Zhang
Oct 30, 2008·Nature Reviews. Genetics·Andreas Wagner
Oct 25, 2017·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Andreas Wagner
Jan 13, 2011·Molecular BioSystems·Karthik Raman, Andreas Wagner
Jun 10, 2017·Cellular and Molecular Life Sciences : CMLS·Joseph B AhrensJessica Siltberg-Liberles
Jul 14, 2020·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·I SatokangasJ Kulmuni
Mar 13, 2020·Scientific Reports·Sergio Forcelloni, Andrea Giansanti

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