Protein S protects against allergic bronchial asthma by modulating Th1/Th2 balance.

Allergy
Kentaro AsayamaEsteban C Gabazza

Abstract

Bronchial asthma is a chronic disease characterized by inflammation, obstruction, and hyperresponsiveness of the airways. There is currently no curative therapy for asthma. Type 2 helper T cell response plays a critical role in the pathogenesis of the disease. Protein S is a glycoprotein endowed with anticoagulant, anti-inflammatory, and anti-apoptotic properties. Whether protein S can suppress bronchial asthma and be useful for its therapy is unknown. To address this question here we compared the development of allergen-associated bronchial asthma between wild type and protein S-overexpressing transgenic mice. Mice were sensitized and challenged with ovalbumin. We also evaluated the circulating levels of total and active protein S in patients with bronchial asthma and healthy controls. The circulating level of total protein S and of its active form was significantly decreased in patients with bronchial asthma compared to controls. Allergic protein S transgenic mice showed a significant reduction of airway hyperresponsiveness, lung tissue inflammatory cell infiltration, lung levels of Th2 cytokines and IgE compared to their wild-type counterparts. Administration of exogenous human protein S also decreased airway hyperresponsive...Continue Reading

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Citations

Oct 1, 2020·Allergy·Lacin CevhertasCezmi A Akdis
Aug 16, 2021·Allergy·Ioana AgacheMarek Jutel
Sep 15, 2021·Allergy·Ismail OgulurCezmi A Akdis

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