Protein structure in membrane domains

Annual Review of Biophysics
Arianna Rath, Charles M Deber

Abstract

Of great interest to the academic and pharmaceutical research communities, helical transmembrane proteins are characterized by their ability to dissolve and fold in lipid bilayers--properties conferred by polypeptide spans termed transmembrane domains (TMDs). The apolar nature of TMDs necessitates the use of membrane-mimetic solvents for many structure and folding studies. This review examines the relationship between TMD structure and solvent environment, focusing on principles elucidated largely in membrane-mimetic environments with single-TMD protein and peptide models. Following a brief description of TMD sequence and conformational characteristics gleaned from the structural database, we present an overview of the conceptual models used to study folding in vitro. The impact of sequence and solvent context on the incorporation of TMDs into membranes, and its role in measurements of TMD self-assembly strengths, is then described. We conclude with a discussion of the nonspecific effects of membrane components on TMD stability.

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Citations

Jun 21, 2014·Protein Science : a Publication of the Protein Society·Irina D PogozhevaAndrei L Lomize
Jul 9, 2016·Annual Review of Biophysics·Martin GruebeleShahar Sukenik
Nov 7, 2016·Biochimica Et Biophysica Acta. Biomembranes·Scott M GordonAlan T Remaley
Feb 12, 2017·The Journal of Physical Chemistry. B·Vikas DubeyDurba Sengupta
May 17, 2017·Nature Communications·David P ScanlonMichael W Salter
Nov 27, 2014·Physical Chemistry Chemical Physics : PCCP·Aiswarya B PawarDurba Sengupta
Jan 21, 2018·The Journal of Membrane Biology·Aiswarya B Pawar, Durba Sengupta
Mar 27, 2015·Biopolymers·Kwang-Im OhFeng Gai
Oct 8, 2013·Physical Chemistry Chemical Physics : PCCP·Xavier PrasannaDurba Sengupta
Jul 20, 2019·Current Opinion in Structural Biology·Georg KrainerMichael Schlierf
Mar 16, 2013·Biochemistry·Vincent G Nadeau, Charles M Deber
Sep 13, 2014·Journal of the American Chemical Society·Ambalika S KhadriaAlessandro Senes

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Methods Mentioned

BETA
protein folding
dissection
circular dichroism
glycosylation
electrophoresis
NMR
FRET

Software Mentioned

MPS3D

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