Protein sulfenic acid-mediated anchoring of gold nanoparticles for enhanced CT imaging and radiotherapy of tumors in vivo.

Nanoscale
Jianan DingHaibin Shi

Abstract

Radiotherapy (RT) has become one of the most widely used treatments for malignant tumors in clinics. Developing a novel radiosensitizer for the integration of precise diagnosis and effective radiotherapy against hypoxic tumors is desirable but remains a great challenge. Herein, protein sulfenic acid reactive gold nanoparticles as effective radiosensitizers were for the first time reported for enhanced X-ray computed tomography (CT) imaging and radiotherapy of tumors in vivo. The gold nanoparticles were decorated with biocompatible poly(ethylene glycol), folic acid (FA), and sulfenic acid reactive groups 1,3-cyclohexanedione (CHD). Such a nanostructure enables on-site immobilization within tumors under oxidative stress through the specific reaction between CHD and endogenous protein sulfenic acids resulting in enhanced accumulation and retention of gold nanoparticles within tumors, which remarkably improves the sensitivity of CT imaging and the radiotherapeutic efficacy of tumors in living mice. This study thus is the first to demonstrate that protein sulfenic acid reactive gold nanoparticles with a tumor anchoring function may serve as effective radiosensitizers for clinical X-ray theranostic application in the future.

References

Feb 22, 1979·Nature·P B SchiffS B Horwitz
Jun 13, 2003·Nature·Rob L M van MontfortHarren Jhoti
Nov 14, 2007·Methods in Enzymology·J Martin Brown
Dec 17, 2008·Chemistry of Materials : a Publication of the American Chemical Society·Chenjie XuShouheng Sun
Jan 17, 2009·Nature Reviews. Cancer·Gillian C BarnettNeil G Burnet
Feb 26, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Amanda LinkousEugenia M Yazlovitskaya
Aug 13, 2009·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tsutomu IwasaKazuhiko Nakagawa
Oct 7, 2009·Proceedings of the National Academy of Sciences of the United States of America·Young Ho Seo, Kate S Carroll
Jan 27, 2010·Nanotechnology·Erika PorcelSandrine Lacombe
Jun 10, 2010·The New England Journal of Medicine·K Kian AngMaura L Gillison
Sep 18, 2010·Chemical Research in Toxicology·Nicholas J Kettenhofen, Matthew J Wood
Mar 15, 2011·Cancer Letters·Rachael R SchulteEugenia M Yazlovitskaya
Jul 21, 2011·British Journal of Cancer·K J HarringtonT Illidge
Dec 18, 2012·Oncoimmunology·George Klein
May 8, 2013·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·C MirjoletN Millot
Aug 15, 2015·Cancer Letters·Yu Sun
Dec 30, 2015·Advanced Drug Delivery Reviews·Sohyoung HerChristine Allen
Jan 16, 2016·ACS Applied Materials & Interfaces·Behnaz GhaemiAmir Amani
Feb 10, 2016·Oncotarget·Elisa PaolicchiStefano Landi
Aug 16, 2016·Biomaterials·Anastasia K HauserJ Zach Hilt
Nov 22, 2016·Cancer Nanotechnology·Kaspar HaumeNigel J Mason
Nov 24, 2016·Theranostics·Xiangzhao AiBengang Xing
Nov 18, 2018·Chembiochem : a European Journal of Chemical Biology·Huawei XiaHaibin Shi
Jan 9, 2019·CA: a Cancer Journal for Clinicians·Rebecca L SiegelAhmedin Jemal
Mar 21, 2019·ACS Chemical Biology·Lisa J AlcockJustin M Chalker

❮ Previous
Next ❯

Citations

May 10, 2021·Materials Science & Engineering. C, Materials for Biological Applications·Linna ChangZhenhua Chen
May 21, 2021·Frontiers in Chemistry·Haiwei WangWei Huang

❮ Previous
Next ❯

Methods Mentioned

BETA
X-ray
dynamic
transmission electron microscopy
electrophoresis
flow cytometry
xenografts

Related Concepts

Related Feeds

Cancer Imaging

Imaging techniques, including CT and MR, have become essential to tumor detection, diagnosis, and monitoring. Here is the latest research on cancer imaging.

Related Papers

Biochimica Et Biophysica Acta
Vinayak Gupta, Kate S Carroll
Archives of Biochemistry and Biophysics
Daniel Mansuy, Patrick M Dansette
Chemical Reviews
N KHARASCHH L WEHRMEISTER
Journal of the American Chemical Society
Thomas H PooleS Bruce King
© 2021 Meta ULC. All rights reserved