Protein surface functionalisation as a general strategy for facilitating biomimetic mineralisation of ZIF-8

Chemical Science
Natasha K MaddiganChristian J Doonan

Abstract

The durability of enzymes in harsh conditions can be enhanced by encapsulation within metal-organic frameworks (MOFs) via a process called biomimetic mineralisation. Herein we show that the surface charge and chemistry of a protein determines its ability to seed MOF growth. We demonstrate that chemical modification of amino acids on the protein surface is an effective method for systematically controlling biomimetic mineralisation by zeolitic imidazolate framework-8 (ZIF-8). Reaction of surface lysine residues with succinic (or acetic) anhydride facilitates biomimetic mineralisation by increasing the surface negative charge, whereas reaction of surface carboxylate moieties with ethylenediamine affords a more positively charged protein and hinders the process. Moreover, computational studies confirm that the surface electrostatic potential of a protein is a good indicator of its ability to induce biomimetic mineralisation. This study highlights the important role played by protein surface chemistry in encapsulation and outlines a general method for facilitating the biomimetic mineralisation of proteins.

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Citations

Aug 29, 2018·Chemistry, an Asian Journal·Guixian ZhuLianqing Zhu
Apr 24, 2020·Chemical Communications : Chem Comm·Raffaele RiccoPaolo Falcaro
Aug 20, 2020·Chemical Communications : Chem Comm·Qun YuJiwei Cui
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Jan 14, 2021·Chemical Reviews·Weibin LiangChristian J Doonan
Sep 24, 2020·Chemical Communications : Chem Comm·Michael R HafnerPaolo Falcaro
Mar 7, 2021·Journal of Hazardous Materials·Lina YangMengxia Xie
May 8, 2021·ACS Applied Materials & Interfaces·Natasha K MaddiganChristian J Doonan
May 14, 2021·International Journal of Biological Macromolecules·Jie ZhengRobert J Linhardt
Jun 8, 2021·Chemical Science·Miriam de J Velásquez-HernándezPaolo Falcaro
Jun 12, 2021·Chemistry, an Asian Journal·Fang WangJianping Lei
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Oct 5, 2021·Chemical Communications : Chem Comm·Nicholas G White

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Methods Mentioned

BETA
acetylation
X-ray
electrophoresis

Software Mentioned

DELPHI
Biopython
Mercury
SURFPOT
PDB2PQR
WinPlotr

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