PMID: 9187630Jun 1, 1997Paper

Protein synthesis and degradation change rapidly in response to food intake in muscle of food-deprived mice

The Journal of Nutrition
Fumiaki YoshizawaR Funabiki

Abstract

The short-term changes in muscle protein synthesis and degradation after food intake are unclear. We investigated muscle protein metabolism after food intake in mice that were starved for 18 h and refed for 1 h. Protein synthesis activity was estimated by the polysome profiles, and protein degradation was estimated by plasma N tau-methylhistidine (MeHis) concentration, reflecting translational activity and myofibrillar protein degradation, respectively. MeHis is an index of myofibrillar protein degradation because it is not reused for protein synthesis and it is not metabolized. Stimulation of protein synthesis (polysome profile) and the reduction of protein degradation (plasma N tau-methylhistidine concentration) were observed immediately after feeding began. Protein synthesis returned to the prefeeding level by 6 h after refeeding, whereas protein degradation remained at a low level. The decreased plasma MeHis concentration after refeeding was not due to a decrease in MeHis release from muscle cells and an increase in the free MeHis pool size, because the changes in free MeHis concentration in muscle were similar to that of plasma. Plasma insulin concentration immediately rose with feeding and it returned to the prefeeding le...Continue Reading

References

Jan 1, 1991·The Biochemical Journal·P H Sugden, S J Fuller
Dec 1, 1986·Metabolism: Clinical and Experimental·B B LowellM N Goodman
Aug 1, 1985·Journal of Nutritional Science and Vitaminology·M KadowakiH Naito
Apr 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G E MortimoreC A Surmacz
Feb 1, 1995·Bioscience, Biotechnology, and Biochemistry·F YoshizawaR Funabiki

❮ Previous
Next ❯

Citations

Oct 20, 2009·Human Molecular Genetics·Amy S LeonardsonEric E Schadt
Oct 1, 2007·Animal : an International Journal of Animal Bioscience·J F HocquetteI Ortigues-Marty
May 19, 2020·American Journal of Physiology. Endocrinology and Metabolism·Jaclyn E WellesScot R Kimball
Feb 11, 2005·European Journal of Applied Physiology·L DeldicqueM Francaux
Mar 7, 2013·Journal of Animal Science·S C PearceL H Baumgard
Dec 4, 1998·Bioscience, Biotechnology, and Biochemistry·T NagasawaN Nishizawa
Jul 19, 2008·Nutrition & Metabolism·Nelo E ZanchiAntonio H Lancha
Mar 22, 2007·European Journal of Clinical Nutrition·J López HellínE García-Arumí
Sep 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·C MorensD Tomé
Mar 13, 2014·Animal Science Journal = Nihon Chikusan Gakkaihō·Masahisa IbukiHiroshi Kamisoyama
Jan 19, 2008·Journal of Nutritional Science and Vitaminology·Takayuki SugawaraTakashi Nagasawa
Jan 5, 2017·Scientific Reports·Takuya IshikawaYoshiharu Shimomura
Nov 14, 1998·The American Journal of Physiology·F YoshizawaL S Jefferson
Oct 15, 2020·ELife·Timothy J DuerrJames R Monaghan
Jun 1, 2003·Nutrition Research Reviews·Dominique DardevetJean Grizard
Oct 9, 2007·Respiratory Physiology & Neurobiology·Cristina M DiasPatricia R M Rocco

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.