Dec 7, 2007

Protein synthesis inhibition and memory: formation vs amnesia

Neurobiology of Learning and Memory
Paul E Gold

Abstract

Studies using protein synthesis inhibitors have provided key support for the prevalent view that memory formation requires the initiation of protein synthesis as a primary element of the molecular biology of memory. However, many other interpretations of the amnesia data have received far less attention. These include: (a) protein synthesis may play a constitutive role in memory formation, providing proteins prior to an experience that can be activated by training; (b) protein synthesis may be needed to replace proteins available prior to learning but 'consumed' by learning; (c) inhibition of protein synthesis impairs the well-being of neurons, leading to an inability to deliver resources needed for memory formation; and (d) inhibition of protein synthesis results in abnormal neural functions that interfere with memory. One of these, abnormal release of neurotransmitters after inhibition of protein synthesis, is detailed here, along with a review of many circumstances in which it appears that protein synthesis at the time of training is not required for the formation of new memories. Evidence of activation of cell signaling molecules and transcription factors is another form of support for a role of training-initiated protein s...Continue Reading

Mentioned in this Paper

Anisomycin
DRUG Screen Quant Caffeine
Cyclic AMP-Responsive DNA-Binding Protein
Protein Degradation, Regulatory
Physiologic Pulse
Discrimination Learning
Amnesia
Neurotransmitter Secretion
Genome
Post-Translational Protein Processing

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