PMID: 42989Aug 1, 1979

Protein synthesis inhibition in rat liver by the mycotoxin patulin

Toxicology
F Hatey, Y Moulé

Abstract

Patulin, a carcinogenic mycotoxin, inhibits in vivo and in vitro protein synthesis in rat liver. The in vivo inhibition culminates 5 h after toxin administration and reaches a maximum of 65% with regard to control values; a breakdown of polysomes is associated with the translational blockage. However in in vitro systems, the cellular fractions obtained from patulin-treated rats appear equally as active in protein synthesizing ability and as sensitive to the toxin action as those prepared from control animals. The in vitro inhibition by patulin is dose related. The postmitochondrial system is less sensitive than that functioning with isolated polysomes and pH 5 enzyme. This difference might be due to the presence of soluble factor(s) that counteract patulin action. We propose that the inhibition of protein synthesis by patulin may result from an interaction of the drug with active SH groups at the membrane level (amino acid transport, ion equilibrium) and/or at the cytoplasmic level (enzymes and factors involved in the translational process).

References

Mar 30, 2004·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Güldeniz Selmanoglu, E Arzu Koçkaya
Aug 17, 2005·Toxicology and Applied Pharmacology·Ting-Shuan WuBiing-Hui Liu
Dec 31, 1985·Chemico-biological Interactions·W ArafatG Dirheimer
Jul 25, 2017·International Journal of Environmental Research and Public Health·Ahmed A Ismaiel, Jutta Papenbrock

Citations

Jul 15, 1971·International Journal of Cancer. Journal International Du Cancer·A Demarle, Y Moulé

Related Concepts

Polyribosomes
Set of Polysomal Ribosomes
Patulin
Depression, Chemical
Enzymes, antithrombotic
Toxin
Protein Biosynthesis
Soluble
Cytoplasmic
Enzymes for Treatment of Wounds and Ulcers

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