PMID: 2121538Oct 15, 1990Paper

Protein TAU variants present in paired helical filaments (PHFs) of Alzheimer brains

FEBS Letters
Y GacheJ Nunez

Abstract

Polyclonal anti-TAU antisera directed against native Tau protein and the NH2-terminal side of the mouse TAU sequence were used to determine the nature of the TAU variants present in Alzheimer brains and in PHFs. These antibodies labelled specifically neurofibrillary tangles and plaque neurites in Alzheimer brains. On immunoblots of PHF extracts, two entities of 69 and 130 kDa were identified. These TAU-related species were absent from control brains. Protein immunoblot of total Alzheimer and control supernatants were shown to contain the same 4-5 TAU variants but none of the 69 and 130 TAU-related entities found in PHFs. These data suggest that specific TAU species are present in PHFs.

References

Jun 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·J G WoodL I Binder
Sep 1, 1989·Journal of the Neurological Sciences·S FlamentA Défossez
Jan 1, 1989·Annual Review of Neuroscience·D J Selkoe
Jul 1, 1986·Proceedings of the National Academy of Sciences of the United States of America·I Grundke-IqbalL I Binder
Jun 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·C M WischikA Klug
Jul 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·R C PearsonT P Powell
Jul 1, 1982·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·G Childs, G Unabia

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Citations

May 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·D CouchieJ Nunez
Jun 1, 1992·Journal of Neurochemistry·Y GacheJ Nunez
Feb 1, 1992·Pathology, Research and Practice·P DustinJ Flament-Durand

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