PMID: 8938133Nov 1, 1996Paper

Protein topology of presenilin 1

Neuron
A DoanS S Sisodia

Abstract

Mutations in a gene encoding a multitransmembrane protein, termed presenilin 1 (PS1), are causative in the majority of early-onset cases of AD. To determine the topology of PS1, we utilized two strategies: first, we tested whether putative transmembranes are sufficient to export a protease-sensitive substrate across a lipid bilayer; and second, we examined the binding of antibodies to specific PS1 epitopes in cultured cells selectively permeabilized with the pore-forming toxin, streptolysin-O. We document that the "loop," N-terminal, and C-terminal domains of PS1 are oriented toward the cytoplasm.

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Citations

Jun 16, 1999·Journal of Neuroscience Research·Q GuoM P Mattson
Sep 24, 1999·Molecular Neurobiology·F Checler
Mar 5, 2011·Journal of Neural Transmission·Paul R PenningtonDarrell D Mousseau
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Nov 11, 1999·Genes & Development·D B DonovielA Bernstein

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