Protein translocation into the ERGIC: an upstream event of secretory autophagy.

Autophagy
Lei LiuLiang Ge

Abstract

Macroautophagy/autophagy was recently shown to regulate unconventional protein secretion through a process called secretory autophagy. How the secretory cargo selectively enters into the secretory autophagosome has been a central question. Our recent studies indicate that cargo translocation into the ER-Golgi intermediate compartment, a compartment contributing membranes to the forming autophagosome, acts as a mechanism for secretory cargo entry into the vesicle and may be an early step for secretory autophagy.

Citations

Oct 6, 2020·Frontiers in Cell and Developmental Biology·Shuwen DengWei Lu
Dec 29, 2020·Frontiers in Molecular Biosciences·Sreedevi Padmanabhan, Ravi Manjithaya
Nov 7, 2020·Journal of Cell Science·Maria Teresa Pallotta, Walter Nickel

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