PMID: 2109053Apr 1, 1990Paper

Protein turnover in malnourished patients with cystic fibrosis: effects of elemental and nonelemental nutritional supplements

Journal of Pediatric Gastroenterology and Nutrition
J T PelekanosR W Shepherd

Abstract

To evaluate the relative efficacy of nonelemental versus semielemental enteral supplements for nutritional rehabilitation of cystic fibrosis (CF) patients, whole-body protein turnover using the [15N]glycine method was studied in nine malnourished CF patients during enteral feedings, in a block design study comparing a semielemental formula (Criticare), a higher protein density but nonelemental formula (Traumacal) (T), and a nonelemental formula that had been modified to become isocaloric and isonitrogenous to the semielemental formula (modified Traumacal, MT). No significant differences in rates of protein synthesis or catabolism were observed comparing the three formulas. However, the higher protein density nonelemental formula resulted in higher net protein deposition compared to the other two formulas (T + 0.42 g kg-1 10 h-1 versus 0.33 g kg-1 10 h-1 for Criticare and -0.59 g kg-1 10 h-1 for MT), although this was significant (p less than 0.05) for the MT versus T comparison only. This study lends support to the use of less expensive nonelemental formulas for the nutritional management of malnourished patients with CF.

Citations

Mar 22, 2007·Nutrition in Clinical Practice : Official Publication of the American Society for Parenteral and Enteral Nutrition·Jamie M ErskineMarci Sontag
Jul 23, 2019·The Cochrane Database of Systematic Reviews·Deirdre ShimminTracey Remmington
May 28, 2015·The Cochrane Database of Systematic Reviews·Damian K FrancisRuth M Watling
Mar 10, 2005·The American Journal of Clinical Nutrition·Vincent G M GeukersHans P Sauerwein
Apr 10, 2015·The Cochrane Database of Systematic Reviews·Alison Morton, Susan Wolfe

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