Protein turnover in skeletal muscle of suckling rats.

The American Journal of Physiology
T A DavisP J Reeds

Abstract

To determine the normal changes in protein turnover of skeletal muscle in vivo during the suckling period of rats, protein synthesis was measured in soleus, plantaris, anterior tibialis, and extensor digitorum longus (EDL) muscles of 1- to 28-day-old rats using a flooding dose of L-[4-3H]phenylalanine. Protein mass of hind-limb muscles increased nearly 100-fold, and RNA increased approximately 20-fold between 1 and 28 days of age. The total amount of protein synthesized per day increased 34-fold. Fractional protein synthesis rates (Ks) decreased two- to threefold between 1 and 28 days postpartum as a result of a decrease in protein synthetic capacity (RNA/protein). Protein synthetic efficiency (total protein synthesized/RNA) increased during this period. Ks were similar among the four muscles at 1-10 days. At 16 days, Ks increased in soleus and plantaris as a result of increases in protein synthetic efficiency; Ks did not increase in anterior tibialis and EDL. These data suggest that, during the suckling period, protein synthetic capacity in skeletal muscles of rats declines, while protein synthetic efficiency increases. The increase in translational efficiency occurred earlier in weight-bearing muscles (soleus, plantaris) than...Continue Reading

Citations

Oct 29, 2000·American Journal of Physiology. Endocrinology and Metabolism·S R KimballT A Davis
Feb 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Scot R KimballTeresa A Davis
Jan 13, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeffery EscobarTeresa A Davis
Nov 10, 2005·American Journal of Physiology. Endocrinology and Metabolism·Jeffery EscobarTeresa A Davis
Jul 20, 2007·The Journal of Nutrition·Thomas C Vary, Christopher J Lynch
Sep 6, 2007·Journal of Animal Science·T A DavisM L Fiorotto
Nov 7, 2013·American Journal of Physiology. Endocrinology and Metabolism·Scott M WheatleyTeresa A Davis
May 5, 2016·American Journal of Physiology. Endocrinology and Metabolism·Michelle KaoTeresa A Davis
May 30, 2003·American Journal of Physiology. Endocrinology and Metabolism·Scot R KimballTeresa A Davis
Mar 15, 2003·American Journal of Physiology. Endocrinology and Metabolism·Pamela M J O'ConnorTeresa A Davis
Oct 12, 2001·American Journal of Physiology. Endocrinology and Metabolism·A SuryawanT A Davis
Dec 19, 2002·American Journal of Physiology. Endocrinology and Metabolism·Weihua ShenEdward A Liechty
Feb 6, 2004·American Journal of Physiology. Endocrinology and Metabolism·Pamela M J O'ConnorTeresa A Davis
Sep 20, 2007·American Journal of Physiology. Endocrinology and Metabolism·Jeffery EscobarTeresa A Davis
Jan 5, 2012·American Journal of Physiology. Endocrinology and Metabolism·Samer W El-KadiTeresa A Davis
Apr 28, 2012·Journal of Molecular Histology·Ludimila Canuto CabeçoMaeli Dal-Pai-Silva
Feb 18, 2016·American Journal of Physiology. Endocrinology and Metabolism·Claire BoutryTeresa A Davis
Sep 11, 2019·American Journal of Physiology. Endocrinology and Metabolism·Jane K NaberhuisTeresa A Davis
Apr 6, 2000·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·M L FiorottoP J Reeds
Jul 14, 2000·American Journal of Physiology. Endocrinology and Metabolism·R C VannT A Davis
Mar 8, 2002·American Journal of Physiology. Endocrinology and Metabolism·Teresa A DavisPamela M J O'Connor
Oct 12, 2002·American Journal of Physiology. Endocrinology and Metabolism·Renan A OrellanaTeresa A Davis
May 8, 2008·American Journal of Physiology. Endocrinology and Metabolism·Fiona A WilsonTeresa A Davis
Jun 7, 2007·American Journal of Physiology. Endocrinology and Metabolism·Asumthia S JeyapalanTeresa A Davis
Jul 11, 2013·American Journal of Physiology. Endocrinology and Metabolism·Claire BoutryTeresa A Davis
Sep 17, 2015·American Journal of Physiology. Endocrinology and Metabolism·Daniel A ColumbusTeresa A Davis
Sep 22, 2018·The American Journal of Clinical Nutrition·Samer W El-KadiTeresa A Davis
Jul 25, 2016·The Journal of Poultry Science·Takaoki SaneyasuHiroshi Kamisoyama
Aug 7, 2008·American Journal of Physiology. Endocrinology and Metabolism·Fiona A WilsonTeresa A Davis
Apr 5, 2001·American Journal of Physiology. Endocrinology and Metabolism·T A DavisH V Nguyen
Sep 10, 2002·American Journal of Physiology. Endocrinology and Metabolism·Teresa A DavisJill A Bush
Oct 22, 2002·American Journal of Physiology. Endocrinology and Metabolism·Pamela M J O'ConnorTeresa A Davis
Nov 30, 2000·American Journal of Physiology. Endocrinology and Metabolism·T A DavisS R Kimball
Mar 11, 2000·American Journal of Physiology. Endocrinology and Metabolism·R C VannT A Davis
Jun 8, 2006·American Journal of Physiology. Endocrinology and Metabolism·Agus SuryawanTeresa A Davis
Jan 1, 2021·Current Developments in Nutrition·Samer W El-KadiTeresa A Davis
Jan 12, 2021·American Journal of Physiology. Endocrinology and Metabolism·Marko RudarTeresa A Davis

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