Protein turnover, lipolysis, and endogenous hormonal secretion in critically ill children

Critical Care Medicine
Paola E CogoFranco Zacchello

Abstract

The catabolic state is a major contributor to morbidity and mortality of critical illness and may be related to endocrine changes. We studied whether protein and lipid turnover correlate with insulin and growth and thyroid hormone plasma levels in critically ill infants. Prospective clinical study. Pediatric intensive care unit. Twelve critically ill children and ten age-matched controls. We measured lipolysis and protein turnover by infusing albumin-bound uniformly 13C palmitic acid and 2H3-leucine for 3 hrs and 2H5-glycerol for 5 hrs to critically ill infants. Simultaneously, we measured serum growth hormones, insulin, C-peptide, thyroid-stimulating hormone, T4, T3, albumin, retinol binding protein (RBP), and prealbumin. Hormone and serum protein levels were also measured in six children when recovered from critical illness. Ten healthy age-matched children served as controls for hormone serum levels comparison. Palmitic acid and glycerol turnover were 5.6 +/- 2.2 micromol/kg/min and 12.2 +/- 7.3 micromol/kg/min, respectively, whereas alpha-ketoisocaproic turnover was 4.9 +/- 2.8 micromol/kg/min. Alpha-ketoisocaproic turnover positively correlated (R = 0.7, p = .03) with duration of pediatric intensive care unit admission and...Continue Reading

References

Sep 1, 1978·Clinical Endocrinology·C WangR T Yeung
Oct 11, 1991·The Journal of Clinical Endocrinology and Metabolism·D R ClemmonsW H Busby
Jul 1, 1991·Critical Care Medicine·R C Bone
Apr 1, 1991·Clinical Science·P J Jones, S T Leatherdale
Sep 5, 1991·The New England Journal of Medicine·D W Wilmore
Jun 1, 1991·Critical Care Medicine·S KleinR R Wolfe
Aug 1, 1990·The American Journal of Physiology·J A ShipR B Wellner
Sep 1, 1989·The Proceedings of the Nutrition Society·A Fleck
Jul 11, 1989·The American Journal of Physiology·A BidaniT D Dubose
Nov 1, 1988·Critical Care Medicine·M M PollackP R Getson
Nov 1, 1987·Baillière's Clinical Endocrinology and Metabolism·S Klein, R R Wolfe
Jun 1, 1987·The Journal of Clinical Investigation·H J MoshageS H Yap
Aug 13, 1987·The New England Journal of Medicine·R R WolfeM Wolfe
Dec 1, 1972·The Journal of Clinical Endocrinology and Metabolism·G L NoelA G Frantz
Feb 1, 1994·Immunology Today·H Baumann, J Gauldie
Jun 1, 1995·Archives of Disease in Childhood·E M LaursenN E Skakkebaek
May 18, 1995·The New England Journal of Medicine·G P Chrousos
Jan 1, 1997·The Journal of Clinical Investigation·G GaribottoA Tizianello
Oct 1, 1996·Baillière's Clinical Endocrinology and Metabolism·P TessariA Tiengo
Feb 1, 1997·The Journal of Clinical Endocrinology and Metabolism·I J Chopra
Apr 1, 1997·Intensive Care Medicine·F A Gibson, C J Hinds
Dec 24, 1997·Proceedings of the Society for Experimental Biology and Medicine·P D LeeD R Powell
Aug 10, 1999·Nutrition Reviews·J P ThissenJ M Ketelslegers

❮ Previous
Next ❯

Citations

Mar 21, 2002·Critical Care Medicine·David M Steinhorn, Satish Kalhan
Feb 4, 2010·Pediatric Critical Care Medicine : a Journal of the Society of Critical Care Medicine and the World Federation of Pediatric Intensive and Critical Care Societies·Barbera De WitNazima Pathan
Apr 30, 2003·Archives of Disease in Childhood·A DurwardI A Murdoch
Mar 2, 2006·Pituitary·C GaunaA J van der Lely
Oct 24, 2007·Clinical Nutrition : Official Journal of the European Society of Parenteral and Enteral Nutrition·Sascha C A T VerbruggenJohannes B van Goudoever
Apr 2, 2009·Paediatric Anaesthesia·Urban Flaring, Yigael Finkel
Sep 2, 2009·Neonatal Network : NN·Patricia Nash
Dec 24, 2009·American Journal of Physiology. Endocrinology and Metabolism·M B WhyteA M Umpleby
Feb 18, 2003·Current Opinion in Clinical Nutrition and Metabolic Care·Comasia A RagusoClaude Pichard
Nov 10, 2007·The American Journal of Clinical Nutrition·Virgilio P CarnielliPaola E Cogo
Oct 5, 2005·Journal of Pediatric Endocrinology & Metabolism : JPEM·Giovanna MarchiniLars-Olof Hansson

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.