Protein tyrosine phosphatase 11 acts through RhoA/ROCK to regulate eosinophil accumulation in the allergic airway

FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Chengyun XuXimei Wu

Abstract

Src homology domain 2-containing protein tyrosine phosphatase 2 (SHP2) participates in multiple cell functions including cell shape, movement, and differentiation. Therefore, we investigated the potential role of SHP2 in eosinophil recruitment into lungs in allergic airway inflammation and explored the underlying mechanism. Both SHP2 and Ras homolog family member A (RhoA) kinase were robustly activated in the airway eosinophils of children with allergic asthma and of a mouse model with allergic airway inflammation. Moreover, inhibition of SHP2 activity by its specific inhibitors reverses the dephosphorylation of p190-A Rho GTPase-activating protein and in turn attenuates RhoA/Rho-associated protein kinase (ROCK) signaling, resulting in the attenuation of eosinophil migration in response to platelet-activating factor stimulation. Specifically, SHP2 deletion in myeloid cells did not affect the number and classification of circulating leukocytes but significantly attenuated the allergen-induced inflammatory cell, especially eosinophil, infiltration into lungs, and airway hyperreactivity. Notably, genetic interaction between RhoA and SHP2 indicated that RhoA inactivation and SHP2 deletion synergistically attenuated the allergen-ind...Continue Reading

References

Jul 1, 1996·Journal of Leukocyte Biology·D CypcarR F Lemanske
Jan 6, 2000·Transgenic Research·B E ClausenI Förster
Feb 22, 2000·The Journal of Biological Chemistry·J A UkropecM J Woolkalis
Apr 9, 2004·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Kenta KobayashiKazuto Kobayashi
Jun 1, 2004·Molecular and Cellular Biology·Maria I KontaridisAnton M Bennett
Sep 18, 2004·Science·Alison A HumblesCraig Gerard
Dec 16, 2005·Molecular and Cellular Biology·Ryouhei TsutsumiMasanori Hatakeyama
Mar 7, 2008·The Journal of Immunology : Official Journal of the American Association of Immunologists·Konrad PazdrakAlexander Kurosky
Jun 19, 2008·The Journal of Cell Biology·Hsiao-Hui Lee, Zee-Fen Chang
Nov 11, 2008·Current Medicinal Chemistry·Hiroaki Kume
Mar 7, 2009·The New England Journal of Medicine·Pranabashis HaldarIan D Pavord
Aug 21, 2009·American Journal of Physiology. Cell Physiology·Jeremy BregeonMalvyne Rolli-Derkinderen
Aug 21, 2009·World Journal of Pediatrics : WJP·Lan-Fang TangZhi-Min Chen
Apr 23, 2011·Biochimica Et Biophysica Acta·Hong-Yi YaoXiao-Feng Yan
Aug 20, 2011·American Journal of Respiratory and Critical Care Medicine·Mario CastroUNKNOWN Res-5-0010 Study Group
Mar 1, 2012·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Xue ZhangYuehai Ke
Aug 15, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fen-Fen LiYuehai Ke
Nov 17, 2012·Nature Reviews. Immunology·Helene F RosenbergPaul S Foster
Feb 28, 2014·British Journal of Pharmacology·Maté BiroWolfgang Weninger
Aug 17, 2014·The Journal of Immunology : Official Journal of the American Association of Immunologists·Bo TaoYuehai Ke
Aug 17, 2014·Current Opinion in Pharmacology·Nadine Anna Caterina Landolina, Francesca Levi-Schaffer
Oct 2, 2014·The Journal of Clinical Investigation·Mallar BhattacharyaDean Sheppard
Dec 3, 2014·The Journal of Allergy and Clinical Immunology·Richard T AmisonSimon C Pitchford
Apr 25, 2015·Nature Reviews. Immunology·Valerie JuliaDavid Dombrowicz
May 21, 2015·Oncotarget·Hongyi YaoZhongmiao Zhang
Aug 10, 2015·Journal of Microbiology, Immunology, and Infection = Wei Mian Yu Gan Ran Za Zhi·Hye Jin LeeJin Tack Kim
Jun 7, 2017·Chest·Elisabeth H Bel, Anneke Ten Brinke
Jul 18, 2017·Frontiers in Medicine·Claire N McBrien, Andrew Menzies-Gow
Oct 14, 2017·Molecular Pharmacology·Musaddique HussainXimei Wu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.