Protein tyrosine phosphatase receptor-type O (PTPRO) exhibits characteristics of a candidate tumor suppressor in human lung cancer

Proceedings of the National Academy of Sciences of the United States of America
Tasneem MotiwalaSamson T Jacob

Abstract

Previous study in our laboratory demonstrated suppression of the gene for protein tyrosine phosphatase receptor-type O (PTPRO) in primary and established rat hepatomas. The present study showed methylation-mediated silencing of this gene in primary human lung tumors and in several human lung cancer cell lines, one of the characteristics of many tumor-suppressor genes. The reduced expression of PTPRO in the primary lung tumors correlated with the methylation status of its CpG island. Demethylation of the gene by deoxy-5-azacytidine treatment led to its reactivation in a lung cancer line (A549). Overexpression of PTPRO in A549 cells inhibited anchorage-independent growth, delayed reentry of the cells into the cell cycle after release from cell-cycle arrest, and increased susceptibility of the cells to apoptosis. These data have demonstrated the growth-suppressor characteristics of PTPRO that are unique to a classical tumor suppressor.

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Citations

Mar 25, 2006·Nature Reviews. Cancer·Arne OstmanFrank D Böhmer
Dec 24, 2010·Nature Reviews. Cancer·Sofi G JulienMichel L Tremblay
Oct 24, 2006·Nature Reviews. Molecular Cell Biology·Nicholas K Tonks
Nov 11, 2008·The Journal of Biological Chemistry·Tasneem MotiwalaSamson T Jacob
Feb 24, 2009·The Journal of Biological Chemistry·Rosanna Pescini GobertRob Hooft van Huijsduijnen
Nov 21, 2012·Molecular and Cellular Biology·Benjamin J ShieldsTony Tiganis
Jun 5, 2007·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Tasneem MotiwalaSamson T Jacob
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Jul 3, 2015·Oncology Reports·Takashi SatoTomoko Betsuyaku
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