Protein tyrosine phosphatases in glioma biology.

Acta Neuropathologica
Anna C NavisWiljan J A J Hendriks

Abstract

Gliomas are a diverse group of brain tumors of glial origin. Most are characterized by diffuse infiltrative growth in the surrounding brain. In combination with their refractive nature to chemotherapy this makes it almost impossible to cure patients using combinations of conventional therapeutic strategies. The drastically increased knowledge about the molecular underpinnings of gliomas during the last decade has elicited high expectations for a more rational and effective therapy for these tumors. Most studies on the molecular pathways involved in glioma biology thus far had a strong focus on growth factor receptor protein tyrosine kinase (PTK) and phosphatidylinositol phosphatase signaling pathways. Except for the tumor suppressor PTEN, much less attention has been paid to the PTK counterparts, the protein tyrosine phosphatase (PTP) superfamily, in gliomas. PTPs are instrumental in the reversible phosphorylation of tyrosine residues and have emerged as important regulators of signaling pathways that are linked to various developmental and disease-related processes. Here, we provide an overview of the current knowledge on PTP involvement in gliomagenesis. So far, the data point to the potential implication of receptor-type (RP...Continue Reading

References

Aug 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·N X Krueger, H Saito
Jan 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·B MosingerM L Tremblay
Jul 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·D E CoolE G Krebs
Aug 2, 1994·Proceedings of the National Academy of Sciences of the United States of America·R NishikawaH J Huang
Mar 1, 1994·Proceedings of the National Academy of Sciences of the United States of America·G J HannonD Beach
Jan 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·A K ChauhanT F Deuel
Jan 1, 1996·Cancer Chemotherapy and Pharmacology·A J McIlwrathR Brown
Dec 1, 1995·Nature Structural Biology·D BarfordN K Tonks
Feb 1, 1997·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J H UhmV W Yong
Aug 19, 1997·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Oct 17, 1998·Journal of the National Cancer Institute·B SouttouA Wellstein
Nov 13, 1998·Proceedings of the National Academy of Sciences of the United States of America·M P MyersN K Tonks
Jul 8, 1999·Current Opinion in Cell Biology·T M Bryan, T R Cech
Jan 27, 2000·Cell·D Hanahan, R A Weinberg
Sep 21, 2000·Seminars in Immunology·M J Ibarra-SánchezM L Tremblay
Dec 1, 2000·Nature·B VogelsteinA J Levine
Oct 13, 2001·Science·S SahaB Vogelstein
Jul 20, 2002·Journal of Neuro-oncology·Satoshi UtsukiKiyotaka Fujii
Nov 9, 2002·The Journal of Biological Chemistry·Fawaz G HajBenjamin G Neel
Dec 12, 2002·The Journal of Biological Chemistry·Helena L PalkaNicholas K Tonks
Feb 18, 2003·Molecular and Cellular Biology·Takamune TakahashiThomas O Daniel
May 2, 2003·Molecular and Cellular Biology·Vladimir N IvanovZe'ev Ronai
Aug 26, 2003·Human Mutation·Charis Eng
Oct 14, 2003·Oncogene·Sabine MüllerThorsten Melcher
Nov 7, 2003·Genes, Chromosomes & Cancer·Ajay PanditaC David James
Dec 3, 2003·Blood·Mignon L LohKevin M Shannon
Dec 25, 2003·Journal of Neuropathology and Experimental Neurology·Ulrike UlbrichtKatrin Lamszus
Feb 10, 2004·Proceedings of the National Academy of Sciences of the United States of America·Nadia DubéMichel L Tremblay
Feb 18, 2004·Nature Reviews. Cancer·Hua Yu, Richard Jove
May 4, 2004·Nature Reviews. Cancer·Mary-Ann Bjornsti, Peter J Houghton

❮ Previous
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Citations

Apr 17, 2012·Neuro-oncology·Harpreet KaurSusann M Brady-Kalnay
Mar 12, 2011·The Journal of Clinical Investigation·Kun-Wei LiuShi-Yuan Cheng
Apr 6, 2013·Neuroscience Bulletin·Jared T Ahrendsen, Wendy Macklin
May 10, 2011·Investigational New Drugs·Zahid M DelwarJuan Sebastian Yakisich
Feb 10, 2016·Scientific Reports·Akihiro FujikawaMasaharu Noda
Sep 4, 2012·The FEBS Journal·Wiljan J A J HendriksJeroen den Hertog
Dec 17, 2014·Pharmacology Research & Perspectives·Michel BernierIrving W Wainer
May 9, 2012·International Journal of Radiation Biology·Mahlon D JohnsonJacqueline P Williams
Jan 19, 2013·Biochimica Et Biophysica Acta·Madhavi MuppiralaGhanshyam Swarup
May 28, 2013·Biochimica Et Biophysica Acta·Wiljan J A J Hendriks, Rafael Pulido
Sep 3, 2016·Acta Neuropathologica Communications·Annika M BourgonjeWiljan J A J Hendriks
May 10, 2017·Cancer Biology & Therapy·Shruti BhargavaKumaravel Somasundaram
Feb 15, 2018·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Wiljan HendriksRafael Pulido
Aug 28, 2018·Journal of Cellular Physiology·Sohini Chakraborty, Zhumur Ghosh
Jan 1, 2013·Tsitologiia·E V Semenova, M V Filatov
Aug 6, 2019·Brain Pathology·Alenka MatjašičDanijela Kolenc
Aug 15, 2012·The Journal of Immunology : Official Journal of the American Association of Immunologists·Fen-Fen LiYuehai Ke
Oct 6, 2011·Journal of Neuro-oncology·Mahlon D JohnsonWebster Pilcher
Jul 19, 2017·Scientific Reports·Akihiro FujikawaMasaharu Noda
Jul 17, 2021·Frontiers in Cell and Developmental Biology·Ya-Nan WangDongjiao Zhang
Jan 28, 2019·Seminars in Cancer Biology·Arata Tomiyama, Koichi Ichimura
Oct 1, 2021·The Protein Journal·Preantha PoonanMahmoud E S Soliman

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Methods Mentioned

BETA
glycosylation
transfection
xenograft
PCR

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Cell Signaling by Tyrosine Kinases

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