PMID: 7539296May 12, 1995Paper

Protein tyrosine phosphorylation as a mechanism which regulates cytokine activation of early response genes

Biochimica Et Biophysica Acta
Andrew C Larner, D S Finbloom

Abstract

Two well-defined rapid responses which occur as a consequence of growth factors binding to their cell surface receptors involve tyrosine phosphorylation of cellular proteins and the induction of the transcription of cellular genes. Recent advances have been made in purification and cloning of Src homology 2 and 3 (SH2/SH3) domain-containing transcription factors which are required for the activation of early response genes by interferons. These transcription factors are covalently modified by tyrosine phosphorylation such that they interact with enhancers needed for interferon-stimulated gene expression. The Jak family of tyrosine kinases are also an integral component in these signalling cascades. The information gained concerning interferon signalling has now been extended to include a broad network of cytokine-regulated signalling systems which use tyrosine phosphorylation of a family of structurally related proteins to activate transcription of early response genes.

References

Apr 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·E Knight, B D Korant
Oct 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·S L GuptaS L Holmes
Dec 15, 1992·Proceedings of the National Academy of Sciences of the United States of America·M A FarrarR D Schreiber
Aug 25, 1992·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Dec 15, 1991·Proceedings of the National Academy of Sciences of the United States of America·R McKendryG R Stark
Sep 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·L M PfefferA R Saltiel
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·N C Reich, L M Pfeffer
Nov 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·X Y FuJ E Darnell
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·D S KesslerJ E Darnell
Feb 1, 1989·Proceedings of the National Academy of Sciences of the United States of America·T C DaleG R Stark
Nov 1, 1984·Proceedings of the National Academy of Sciences of the United States of America·A C LarnerJ E Darnell
Jun 7, 1994·Proceedings of the National Academy of Sciences of the United States of America·G S CampbellC Carter-Su
Jul 19, 1994·Proceedings of the National Academy of Sciences of the United States of America·M DavidA C Larner

❮ Previous
Next ❯

Citations

Nov 1, 1996·Journal of Reproductive Immunology·J S Hunt, S A Robertson
Sep 13, 2000·Molecular and Cellular Biology·K Mowen, M David
Nov 15, 1996·Biochimica Et Biophysica Acta·A Koj
Mar 7, 2001·Arteriosclerosis, Thrombosis, and Vascular Biology·N R MadamanchiM S Runge
Jan 19, 2000·Leukemia·J A McCubreyA Mufson
Apr 8, 2006·The Journal of Biological Chemistry·Ana M GameroAndrew C Larner
Oct 24, 1998·The Journal of Biological Chemistry·Y Ohmori, T A Hamilton
Nov 7, 1998·The Journal of Biological Chemistry·K Mowen, M David
Feb 28, 1998·The Journal of Biological Chemistry·M SakatsumeD S Finbloom
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·M Delgado, D Ganea
Mar 1, 1996·The Journal of Biological Chemistry·M DavidA C Larner
Nov 1, 1995·Cellular Signalling·D S Finbloom, A C Larner
Jan 1, 1996·Cellular Signalling·M B MarreroK E Bernstein

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Scandinavian Journal of Clinical and Laboratory Investigation
N C HenningsenC Borg
European Journal of Cancer : Official Journal for European Organization for Research and Treatment of Cancer (EORTC) [and] European Association for Cancer Research (EACR)
G VoglinoL Fessia
© 2021 Meta ULC. All rights reserved