PMID: 8586072Oct 1, 1995Paper

Protein variability in male and female Wistar rat liver proteins

Electrophoresis
S SteinerP Prieto

Abstract

In the emerging field of mechanistic toxicology, growing attention is being paid to the interpretation of sex-related toxic responses. The Wistar rat outbred stock is a frequently used rodent for toxicity testing. Outbred strains, which display a relatively high degree of genetic variability between the individual animals are often used in risk assessment, as they are considered to best approximate the variability present in a human population. In this study two-dimensional (2-D) protein gel electrophoresis was applied to investigate the liver protein patterns of male and female Wistar rats and to search for (i) sex-related and (ii) interindividual qualitative and quantitative differences in protein expression. Among the sexes, six proteins were detected that were shown to be exclusively present in male rats and one that was present only in females. A male-specific protein was tentatively assigned to alpha 2u globulin. Seven protein spots showed statistically significant abundance changes (p < 0.001) between males and females, one was tentatively assigned to heme oxygenase 1 and another to the 23 kDa morphin-binding protein. Four sets of protein spots were detected that showed positional shifts in the individual patterns and ar...Continue Reading

References

May 1, 1992·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·N L AndersonF C Richardson
Feb 1, 1992·Toxicology and Applied Pharmacology·M D'Amour, M Charbonneau
Jan 1, 1990·Annual Review of Pharmacology and Toxicology·S J BorghoffJ A Swenberg
Jan 1, 1991·Environmental and Molecular Mutagenesis·C A McQueen, B M Way
Jan 1, 1990·Fundamental & Clinical Pharmacology·U A Meyer
Jun 1, 1991·Toxicology Letters·F A Witzmann, D N Parker
Jan 1, 1990·Free Radical Research Communications·R Stocker
Jan 1, 1986·Archives of Toxicology. Supplement. = Archiv Für Toxikologie. Supplement·R L Smith
Apr 15, 1972·Biochimica Et Biophysica Acta·S E Lane, O W Neuhaus
Mar 1, 1966·Proceedings of the Society for Experimental Biology and Medicine·A K Roy, O W Neuhaus
Nov 1, 1982·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·R Kato, T Kamataki
Aug 1, 1994·Protein Science : a Publication of the Protein Society·P JamesG Gonnet
Sep 1, 1993·Toxicology and Applied Pharmacology·J J HuC S Yang
Jun 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·W J HenzelC Watanabe

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Citations

Mar 22, 2000·Electrophoresis·M FountoulakisG Lubec
Sep 18, 1998·Electrophoresis·L AicherS Steiner
Apr 27, 2005·Phytotherapy Research : PTR·R N AlmeidaJ M Barbosa-Filho
Mar 15, 2003·Acta Orthopaedica Scandinavica·Gregor Balaburski, J Patrick O'Connor
Sep 20, 2006·The Journal of Immunology : Official Journal of the American Association of Immunologists·Sei-ichiro TsuchihashiJerzy W Kupiec-Weglinski

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