Protein Z: A putative novel biomarker for early detection of ovarian cancer

International Journal of Cancer. Journal International Du Cancer
Matthew R RussellRobert L J Graham

Abstract

Ovarian cancer (OC) has the highest mortality of all gynaecological cancers. Early diagnosis offers an approach to achieving better outcomes. We conducted a blinded-evaluation of prospectively collected preclinical serum from participants in the multimodal group of the United Kingdom Collaborative Trial of Ovarian Cancer Screening. Using isobaric tags (iTRAQ) we identified 90 proteins differentially expressed between OC cases and controls. A second targeted mass spectrometry analysis of twenty of these candidates identified Protein Z as a potential early detection biomarker for OC. This was further validated by ELISA analysis in 482 serial serum samples, from 80 individuals, 49 OC cases and 31 controls, spanning up to 7 years prior to diagnosis. Protein Z was significantly down-regulated up to 2 years pre-diagnosis (p = 0.000000411) in 8 of 19 Type I patients whilst in 5 Type II individuals, it was significantly up-regulated up to 4 years before diagnosis (p = 0.01). ROC curve analysis for CA-125 and CA-125 combined with Protein Z showed a statistically significant (p = 0.00033) increase in the AUC from 77 to 81% for Type I and a statistically significant (p= 0.00003) increase in the AUC from 76 to 82% for Type II. Protein Z is...Continue Reading

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Citations

Dec 17, 2016·Cellular Oncology (Dordrecht)·Khalid El BairiMariam Amrani
Apr 10, 2018·Obstetrics and Gynecology·Usha MenonAleksandra Gentry-Maharaj
Nov 10, 2017·Mass Spectrometry Reviews·Robert MoulderRiitta Lahesmaa
Jun 12, 2018·Mass Spectrometry Reviews·Iwona BelczackaMaria Frantzi
Dec 3, 2016·Oncotarget·Matthew R RussellRobert L J Graham
Sep 10, 2020·Cancers·Sabine Kasimir-Bauer On Behalf Of The Ovcad Ovarian Cancer Diagnosis Initiative
Aug 8, 2019·British Journal of Cancer·Matthew R RussellRobert L J Graham
Aug 2, 2018·International Journal of Molecular Sciences·Agata SwiatlyZenon J Kokot
Jan 2, 2019·Clinical Proteomics·Jaimie DufresneJohn G Marshall
Oct 3, 2018·Journal of Ovarian Research·Agata SwiatlyZenon J Kokot
Jun 24, 2017·Clinical Cancer Research : an Official Journal of the American Association for Cancer Research·Wei-Lei YangUNKNOWN AOCS Study Group
Aug 14, 2019·Journal of Proteome Research·Bethany GearyAnthony D Whetton

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R
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