Proteinase 3 enhances endothelial monocyte chemoattractant protein-1 production and induces increased adhesion of neutrophils to endothelial cells by upregulating intercellular cell adhesion molecule-1.

Journal of the American Society of Nephrology : JASN
Miriam E J Taekema-RoelvinkMohamed R Daha

Abstract

Wegener's granulomatosis is an autoimmune disease that is characterized by systemic vasculitis and granuloma formation. Early influx of polymorphonuclear neutrophils (PMN), followed at a later stage by mononuclear cells, contributes to the granulomatous inflammation. Previous studies have shown that proteinase 3 (PR3), the major autoantigen in Wegener's granulomatosis, specifically binds to endothelial cells and plays a possible role in activation of these cells by enhancing interleukin-8 production, thus providing a chemotactic and activating stimulus for PMN. The present study demonstrated that PR3 enhances the production of monocyte chemoattractant protein-1 (MCP-1) by human umbilical vein endothelial cells (HUVEC) in a dose- and time-dependent manner. The PR3-induced increase in MCP-1 production was demonstrated at both the protein and the mRNA levels and was chemotactic for monocytes. In addition, it was demonstrated that PR3 induces a dose- and time-dependent increase in the expression of intercellular adhesion molecule-1 (ICAM-1) as determined by fluorescence-activated cell sorter analysis. The PR3-induced increase in expression of ICAM-1 was also demonstrated at the mRNA level. PR3 induced a slight increase in vascular ...Continue Reading

References

Nov 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·T MaciagR Forand
Sep 16, 1992·Biochemical and Biophysical Research Communications·R PigottA J Gearing
Aug 1, 1991·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·J C Jennette
Jun 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·R J FalkJ C Jennette
Mar 10, 1989·Journal of Immunological Methods·P M BathD G Hassall
Jan 1, 1980·Journal of Immunological Methods·W FalkE J Leonard
Dec 1, 1994·European Journal of Immunology·B E BallieuxM R Daha
Feb 1, 1996·Clinical and Experimental Immunology·W J MayetK H Meyer zum Büschenfelde
May 1, 1996·Journal of the American Society of Nephrology : JASN·S P BergerM R Daha
Jan 1, 1996·Journal of the American Society of Nephrology : JASN·H HallerF C Luft
Mar 1, 1997·Kidney International·D SchlöndorffB Banas
Nov 5, 1997·Kidney International·C SegawaH Yokoyama
Aug 26, 1998·Scandinavian Journal of Immunology·M E Taekema-RoelvinkM R Daha
Dec 3, 1999·European Journal of Clinical Investigation·W MayetM Neurath
Apr 7, 2000·Journal of the American Society of Nephrology : JASN·Miriam E J Taekema-RoelvinkMohamed R Daha
May 3, 2000·Kidney International·W F PendergraftG A Preston

❮ Previous
Next ❯

Citations

Jan 16, 2002·Current Opinion in Rheumatology·Caroline O S SavageMark Holland
Jan 1, 2004·Human Immunology·Dominique ReumauxDirk Roos
Apr 24, 2020·Circulation Research·Maximilian J SchlossMatthias Nahrendorf
Feb 3, 2005·International Immunopharmacology·Enrico Maria ZardiAntonella Afeltra
Mar 20, 2012·Circulation Research·Oliver Soehnlein
Apr 15, 2005·International Immunopharmacology·Yanfei HuangLeishi Li
Dec 23, 2006·Néphrologie & thérapeutique·Vincent Louis-Marie EsnaultDominique Besnier
Oct 20, 2006·Journal of the American Society of Nephrology : JASN·Beatrijs D OortwijnCees van Kooten
May 12, 2004·Current Rheumatology Reports·Maria C CidJose Hernández-Rodríguez
Oct 18, 2005·La Presse médicale·P GuilpainL Mouthon
Aug 22, 2009·Blood·Oliver SoehnleinChristian Weber
Aug 25, 2009·Trends in Immunology·Oliver SoehnleinLennart Lindbom
Dec 4, 2009·Journal of Clinical Rheumatology : Practical Reports on Rheumatic & Musculoskeletal Diseases·Robert O HolmesWilliam F Kelly
May 26, 2010·Nature Reviews. Immunology·Oliver Soehnlein, Lennart Lindbom
Aug 7, 2010·Rheumatic Diseases Clinics of North America·Julia FlintCaroline O S Savage

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adhesion Molecules in Health and Disease

Cell adhesion molecules are a subset of cell adhesion proteins located on the cell surface involved in binding with other cells or with the extracellular matrix in the process called cell adhesion. In essence, cell adhesion molecules help cells stick to each other and to their surroundings. Cell adhesion is a crucial component in maintaining tissue structure and function. Discover the latest research on adhesion molecule and their role in health and disease here.

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Related Papers

Journal of the American Society of Nephrology : JASN
Miriam E J Taekema-RoelvinkMohamed R Daha
The Journal of Immunology : Official Journal of the American Association of Immunologists
Akiko UeharaHaruhiko Takada
© 2021 Meta ULC. All rights reserved