PMID: 7544683Apr 1, 1994Paper

Proteinase inhibitor homologues as potassium channel blockers

Nature Structural Biology
J M LancelinD Marion

Abstract

We report here the NMR structure of dendrotoxin I, a powerful potassium channel blocker from the venom of the African Elapidae snake Dendroaspis polylepis polylepis (black mamba), calculated from an experimentally-derived set of 719 geometric restraints. The backbone of the toxin superimposes on bovine pancreatic trypsin inhibitor (BPTI) with a root-mean-square deviation of < 1.7 A. The surface electrostatic potential calculated for dendrotoxin I and BPTI, reveal an important difference which might account for the differences in function of the two proteins. These proteins may provide examples of adaptation for specific and diverse biological functions while at the same time maintaining the overall three-dimensional structure of a common ancestor.

References

May 25, 1977·Journal of Molecular Biology·F C BernsteinM Tasumi
Jun 1, 1992·Protein Science : a Publication of the Protein Society·S G HybertsG Wagner
Jul 16, 1991·Biochemistry·J M LancelinF Inagaki
Jul 20, 1990·Science·B M OliveraL J Cruz
Jan 1, 1985·Pharmacology & Therapeutics·A L Harvey, A J Anderson
Jan 5, 1987·Journal of Molecular Biology·A WlodawerR Huber
Jul 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·H Rehm, M Lazdunski
Oct 1, 1989·Biochemical Pharmacology·A BdolahE Kochva

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Citations

Jun 1, 1996·Journal of Bioenergetics and Biomembranes·J O Dolly, D N Parcej
Aug 11, 2000·Toxicon : Official Journal of the International Society on Toxinology·A L Harvey
Jan 1, 1997·General Pharmacology·A L Harvey
Feb 13, 2001·Gene·D Kordis, F Gubensek
Jan 23, 1999·European Journal of Biochemistry·A Alape-GirónH Jörnvall
Oct 17, 2008·PloS One·Chun-Hua YuanSong-Ping Liang
Nov 29, 2012·Developmental and Comparative Immunology·Shiwanthi Ranasinghe, Donald P McManus
Jun 23, 2007·Neuropharmacology·Abbas Mirshafiey
Jun 23, 2004·Toxicon : Official Journal of the International Society on Toxinology·Besma JouirouJean-Marc Sabatier
Sep 27, 2006·The Journal of Thoracic and Cardiovascular Surgery·Vesa AnttilaRichard A Jonas
Apr 28, 2009·Journal of Molecular Biology·Guido C PaesenRobert M Esnouf
Oct 20, 1995·The Journal of Biological Chemistry·H SchweitzM Lazdunski
Oct 23, 2020·The Journal of Venomous Animals and Toxins Including Tropical Diseases·Roberto Tadashi KodamaFernanda Calheta Vieira Portaro
Nov 20, 2018·Archives of Biochemistry and Biophysics·Seyede Elnaz BanijamaliMitra Maryam Elmi
Jul 10, 2017·Neuropharmacology·Raymond S Norton, K George Chandy

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