Proteinase inhibitory spectrum of mouse murinoglobulin and alpha-macroglobulin.

Journal of Biochemistry
K AbeH Sinohara

Abstract

The interactions of mouse murinoglobulin and alpha-macroglobulin with several proteinases were investigated by filtration and by assays of amidolytic activity towards synthetic substrates in the presence of proteinaceous enzyme inhibitors as well as assays of the inhibition of proteolytic activity. Mouse alpha-macroglobulin formed complexes with thrombin, clotting factor Xa, plasmin, pancreatic kallikrein, plasma kallikrein, submaxillary gland trypsin-like proteinase, neutrophil elastase, and pancreatic elastase. These complexes lost the proteolytic activities against high-molecular-weight substrates, but protected the active sites of the enzymes from inactivation by their proteinaceous inhibitors. Mouse murinoglobulin showed essentially the same properties except (i) that it did not form a complex with the clotting factor Xa, and (ii) that it did not protect plasma kallikrein, neutrophil elastase or submaxillary proteinase from inactivation by their proteinaceous inhibitors, although it formed complexes with these proteinases. No interaction was detected between Clostridium histolyticum collagenase and murinoglobulin or alpha-macroglobulin. These results indicate (i) that murinoglobulin has a proteinase-binding spectrum simila...Continue Reading

Citations

Jun 14, 2017·Medicinal Research Reviews·Nicolas MasurierVincent Lisowski
Aug 25, 1995·The Journal of Biological Chemistry·L UmansH Van den Berghe
Jan 1, 1992·Electron Microscopy Reviews·E DelainF Van Leuven
Jan 1, 1991·Comparative Biochemistry and Physiology. B, Comparative Biochemistry·S AmemiyaH Sinohara
Jul 3, 2021·International Journal of Molecular Sciences·Virginia Actis Dato, Gustavo Alberto Chiabrando
Jul 10, 2010·Biochimie·Peter GoettigHans Brandstetter
Sep 17, 1999·The American Journal of Pathology·L UmansF Van Leuven

❮ Previous
Next ❯

Related Concepts

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.