Proteins and peptides: strategies for delivery to and across the skin

Journal of Pharmaceutical Sciences
Heather A E Benson, Sarika Namjoshi

Abstract

Despite the increased availability of therapeutic proteins and peptides, delivery remains almost entirely via hypodermic needle. Transdermal delivery offers an attractive noninvasive route of administration but is limited by the skin's barrier to penetration. Extensive research has been directed at developing effective methods to enhance delivery of peptides and proteins to and across the skin. Strategies include formulation optimisation, conjugation to increase peptide lipophilicity and incorporation of chemical or biological modifiers to transiently reduce stratum corneum barrier function. A number of physical technologies, including iontophoresis, electroporation and sonophoresis, have been developed that apply different forms of energy to disrupt the barrier. In addition, minimally invasive techniques, such as microneedles and jet propulsion, bypass the stratum corneum barrier to permit direct access to the viable epidermis. This article reviews the current state of the art in the delivery of proteins and peptides to and across the skin.

References

Jul 1, 1990·Journal of Pharmaceutical Sciences·V SrinivasanC R Behl
Oct 1, 1989·Biochemical Society Transactions·H E BoddeM Ponec
Jan 1, 1987·Annals of the New York Academy of Sciences·Y W ChienJ C Liu
Aug 11, 1995·Science·S MitragotriR Langer
Apr 1, 1995·Pharmaceutica acta Helvetiae·I Steinsträsser, H P Merkle
Jun 1, 1994·British Journal of Clinical Pharmacology·D WesterlingP Svedman
Jun 1, 1994·European Journal of Pediatrics·U SchneiderE Schober
Nov 15, 1993·Proceedings of the National Academy of Sciences of the United States of America·M R PrausnitzJ C Weaver
Apr 1, 1993·Journal of Cellular Biochemistry·J C Weaver
Jan 28, 1998·Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine·A J SingerS A McClain
Nov 1, 1995·Bio/technology·M R PrausnitzJ C Weaver
Aug 4, 1998·Journal of Pharmaceutical Sciences·S HenryM R Prausnitz
Nov 5, 1999·Skin Pharmacology and Applied Skin Physiology·E H ChoiS M Hwang
Feb 29, 2000·International Journal of Pharmaceutics·J GuoC Jiao
Mar 4, 2000·Journal of Controlled Release : Official Journal of the Controlled Release Society·E TouitouM Eliaz
Jun 14, 2000·International Journal of Pharmaceutics·S L ChangA K Banga
Jun 22, 2000·Journal of Pharmaceutical Sciences·S MitragotriR Langer
Nov 21, 2000·Biological & Pharmaceutical Bulletin·T OgisoA Ito
Apr 11, 2001·Lasers in Surgery and Medicine·S LeeA G Doukas
Jul 14, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·W R LeeJ Y Fang
Aug 14, 2001·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·B W Barry
Oct 27, 2001·Biosensors & Bioelectronics·M J TierneyUNKNOWN Cygnus Research Team
Feb 8, 2002·Journal of Peptide Science : an Official Publication of the European Peptide Society·Albert Loffet
Jul 9, 2002·Biochimica Et Biophysica Acta·Arindam SenSek Wen Hui
Jul 13, 2002·Journal of Pharmaceutical Sciences·Woan-Ruoh LeeJia-You Fang
Aug 15, 2002·Journal of Controlled Release : Official Journal of the Controlled Release Society·Arindam SenSek Wen Hui
Sep 27, 2002·Biophysical Journal·Arindam SenSek Wen Hui
Nov 14, 2002·International Journal of Pharmaceutics·N Kanikkannan, Mandip Singh
Mar 12, 2003·Advanced Drug Delivery Reviews·Sarah L Tao, Tejal A Desai
Mar 12, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Omathanu Pillai, Ramesh Panchagnula
Apr 16, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Omathanu Pillai, Ramesh Panchagnula
Apr 25, 2003·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amnon C SintovGalit Levin
May 23, 2003·Journal of Pharmaceutical Sciences·R Alvarez-RománR H Guy
Jun 24, 2003·Comparative Immunology, Microbiology and Infectious Diseases·Hansi J DeanJorge E Osorio
Jul 4, 2003·The Journal of Investigative Dermatology·Gopinathan K MenonApostolos G Doukas
Aug 13, 2003·Critical Reviews in Therapeutic Drug Carrier Systems·Biana Godin, Elka Touitou
Aug 30, 2003·Ultrasound in Medicine & Biology·Nadine Barrie SmithK Kirk Shung
Sep 5, 2003·International Journal of Pharmaceutics·Babu M Medi, Jagdish Singh
Aug 1, 1962·Journal of Pharmaceutical Sciences·W I HIGUCHI
Nov 19, 2003·Proceedings of the National Academy of Sciences of the United States of America·Devin V McAllisterMark R Prausnitz

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Citations

Mar 26, 2011·Pharmaceutical Research·Katarzyna MigalskaRyan F Donnelly
Jun 30, 2009·Pigment Cell & Melanoma Research·Zalfa A Abdel-MalekJames J Knittel
Jan 10, 2013·The Journal of Clinical Investigation·Volker SpindlerJens Waschke
Dec 3, 2009·Yakugaku zasshi : Journal of the Pharmaceutical Society of Japan·Masahiro SuginoKenji Sugibayashi
May 8, 2013·Therapeutic Delivery·Maelíosa T C McCruddenRyan F Donnelly
Jan 1, 2014·Drug Development and Industrial Pharmacy·Jianmin ChenYunhua Gao
Oct 18, 2016·Drug Delivery·Karmen Cheung, Diganta B Das
Jan 10, 2013·Drug Development and Industrial Pharmacy·Javier O MoralesJason T McConville
Apr 24, 2014·Cutaneous and Ocular Toxicology·Margaret E K KraelingOluwatosin A Ogunsola
Oct 21, 2010·Journal of Pharmaceutical Sciences·Yuly A Jaimes-LizcanoKyriakos D Papadopoulos
Jan 6, 2010·Journal of Pharmaceutical Sciences·Dipak S PisalSathy V Balu-Iyer
Oct 16, 2012·Journal of Controlled Release : Official Journal of the Controlled Release Society·Amit AlexanderDulal Krishna Tripathi
Jul 1, 2012·Drug Discovery Today. Technologies
Jul 20, 2011·International Journal of Pharmaceutics·Utpal U ShahUNKNOWN NIHR MCRN/Arthritis Research UK Paediatric Rheumatology Clinical Studies Group
Sep 10, 2015·Drug Delivery and Translational Research·Ali Aghazadeh-HabashiMichael R Doschak
Feb 9, 2012·International Journal of Pharmaceutics·C Loira-PastorizaP Maincent
Aug 17, 2016·Biotechnology Journal·Momoko KitaokaMasahiro Goto
Jan 11, 2017·Molecular Pharmaceutics·Abhay U AndarShiladitya DasSarma
Apr 21, 2017·Drug Delivery·Joon LeeWon-Serk Kim
Mar 25, 2017·Journal of Pharmaceutical Sciences·Hanif HaidariSanjay Garg
Jan 24, 2014·Acta ortopedica brasileira·Fabiano Inácio de SouzaTarcísio Eloy Pessoa de Barros Filho
Mar 3, 2017·Physical Chemistry Chemical Physics : PCCP·Rakesh GuptaBeena Rai
Jan 27, 2018·Scientific Reports·Seng Han LimLifeng Kang
Jun 12, 2018·Expert Review of Pharmacoeconomics & Outcomes Research·Jolanda Richter-JohnsonViness Pillay
Jun 22, 2010·Biopolymers·Sarika Namjoshi, Heather A E Benson
May 30, 2015·Pharmacological Reviews·Miia KovalainenKarl-Heinz Herzig
Jan 8, 2020·Expert Opinion on Drug Delivery·Andrej KováčikKateřina Vávrová
Feb 26, 2020·Pharmaceutical Development and Technology·Shahram Emami, Ali Shayanfar
Mar 12, 2017·Amino Acids·Filipa C SantosSusana P G Costa
Aug 22, 2014·Biomolecules & Therapeutics·Yun Lim ChoiYoung-Hee Shin
Jul 29, 2010·Biopolymers·Gayathri KrishnanHeather A E Benson
Dec 22, 2019·International Journal of Molecular Sciences·Sekyoo JeongHyun Jung Kim

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