PMID: 1385728Jul 9, 1992Paper

Proteins derived from platelet alpha granules modulate the uptake of oxidized low density lipoprotein by macrophages

Biochimica Et Biophysica Acta
B FuhrmanM Aviram

Abstract

Activated platelets secrete from their alpha granules a protein-like factor which stimulates the uptake of oxidized low-density lipoprotein (Ox-LDL) by macrophages. The aim of the present study was to evaluate the effect of three purified proteins obtained from platelet alpha granules: platelet-derived growth factor (PDGF), platelet factor-4 (PF-4), and beta-thromboglobulin (B-TG), on the uptake of Ox-LDL by macrophages. Cellular degradation of Ox-LDL by the J-774 A.1 macrophage-like cell line, that was preincubated for 18 h at 37 degrees C, with increasing concentrations of partially purified PDGF, (designated PDGF-CMS-III) was increased by up to 36% in comparison to control cells preincubated without PDGF. This effect was due to PDGF-mediated increase in the number of macrophage receptors for Ox-LDL. The enhanced uptake of Ox-LDL by PDGF resulted in an increase in cellular cholesterol content. Preincubation of macrophages with two types of recombinant PDGF dimers (10 ng/ml), revealed that PDGF-BB stimulated Ox-LDL cellular degradation by 64%, whereas PDGF-AB demonstrated only 34% stimulation, in comparison to control cells that were not treated with PDGF. The stimulatory effect of PDGF-CMS-III and PDGF-AB were reduced by 20% ...Continue Reading

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Citations

Apr 1, 1995·Cell and Tissue Research·B ZhaoR Dierichs
Mar 1, 1993·Blood Reviews·P Harrison, E M Cramer
Feb 22, 2002·The Journal of Surgical Research·J Jeffrey Alexander, Isabel Lewis
Jan 11, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·A Corsini
Mar 24, 2005·Journal of Cellular and Molecular Medicine·D A ArvanitisD A Spandidos

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