PMID: 9175467May 1, 1997Paper

Proteins, RNAs and chaperones in enzyme evolution: a folding perspective

Trends in Biochemical Sciences
P Csermely

Abstract

The present roles of RNA molecules as templates and of proteins as cellular catalysts may not have always been so clearly defined during evolution. Recent work on ribozymes shows that the catalytic activity of early RNAs may have been more general than previously thought. How did evolution select proteins, not RNA, to be the major biological catalysts? Why were chaperones necessary for the evolution of modern protein enzymes?

Citations

Aug 5, 2003·BioFactors·Eszter PappPéter Csermely
Jan 9, 2001·Archives of Biochemistry and Biophysics·G NardaiP Csermely
Jan 15, 1999·Pathology Oncology Research : POR·C Soti, P Csermely
Oct 13, 2009·Cell Stress & Chaperones·Attila MolvarecJános Rigó
Sep 6, 2002·Neurochemistry International·Csaba Söti, Péter Csermely
Sep 2, 1999·Trends in Biochemical Sciences·C M Dobson
Feb 1, 2012·PloS One·Folkert K de Boer, Paulien Hogeweg
Oct 17, 2002·Cell Stress & Chaperones·Csaba Soti, Péter Csermely
Sep 20, 2005·British Journal of Pharmacology·Csaba SõtiPéter Ferdinandy
Aug 12, 2005·Journal of Molecular Recognition : JMR·Vladimir N UverskyA Keith Dunker
Apr 5, 2013·Protein Science : a Publication of the Protein Society·Vladimir N Uversky
Nov 6, 2012·Journal of Zhejiang University. Science. B·Rui BaiShu Zheng
May 22, 2009·Acta Physiologica Hungarica·Tibor Károly FábiánP Fejérdy
Jul 31, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Peter Tompa, Peter Csermely
Jan 31, 2002·World Journal of Gastroenterology : WJG·Beatrice D Darimont
Feb 25, 2017·Intrinsically Disordered Proteins·Zhenling PengLukasz Kurgan

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