PMID: 6982758Oct 1, 1982Paper

Proteins synthesized by inducer T cells: evidence for a mitogenic peptide shared by inducer molecules that stimulate different cell types

Cell
M FresnoH Cantor

Abstract

Inducer T lymphocytes synthesize and secrete peptides that stimulate growth and differentiation of many cell types, including lymphocytes and monocytes that kill foreign organisms, B lymphocytes, mast cells and hematopoietic precursor cells. To define these inducer molecules more precisely, we have generated clones of these T cells as a source of homogeneous material for biochemical analysis. These clones synthesize peptides that stimulate T and B cells to divide and that also induce the latter cells to secrete immunoglobulin. Inducer cells synthesize a 14 kilodalton growth polypeptide that stimulates T and B lymphocytes, as well as other cell types, to divide. This 14 kilodalton peptide is normally associated with different, larger peptides that appear to focus its mitogenic activity to one or another target cell.

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Citations

Jan 1, 1987·Immunology Letters·J M RedondoM Fresno
Oct 1, 1996·Cytokine & Growth Factor Reviews·G F Weber, H Cantor
Jul 1, 1983·Proceedings of the National Academy of Sciences of the United States of America·G J FreemanH Cantor
Apr 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·R PatarcaK A Johnson
Aug 2, 2003·Biology of Reproduction·Greg A JohnsonThomas E Spencer
Oct 1, 1984·Cellular Immunology·R SchwartingC Y Wang
Jun 4, 1998·Biochemical and Biophysical Research Communications·J J Liang, B Chakrabarti
Mar 1, 2002·Biology of Reproduction·Jane E GarlowFuller W Bazer
Jan 1, 1982·Journal of Cellular Biochemistry·H Cantor
Feb 24, 2009·Genome Génome / Conseil National De Recherches Canada·Giovanni A L BrogginiAndrea Patocchi

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