Proteinuria and risk for stroke and coronary heart disease during 27 years of follow-up: the Honolulu Heart Program

Archives of Internal Medicine
James R MadisonJ David Curb

Abstract

Urinary protein excretion has been linked to coronary heart disease (CHD); the relationship to stroke is less clear. We assessed whether urine dipstick screening for protein predicted stroke and CHD in the Honolulu Heart Program cohort. Prospective, observational study of 6252 Japanese American men in Honolulu aged 45 to 68 years. Proteinuria was detected by means of urine dipstick screening during the first and third examinations. Subjects were classified as having no proteinuria if results were negative at both examinations, transient proteinuria if results were positive at 1 examination, and persistent proteinuria if results were positive at both examinations. Relative risk was derived using those subjects with no proteinuria as the reference. Outcomes were assessed through 27 years. No proteinuria was found in 92.8% of subjects, transient proteinuria in 6.1%, and persistent proteinuria in 1.1%. The age-adjusted incident stroke rates were 3.7, 7.3, and 11.8 per 1000 person-years in subjects with no, transient, or persistent proteinuria, respectively (P<.001). Age-adjusted rates of incident CHD were 9.4, 15.8, and 35.2 events per 1000 person-years, respectively (P<.001). Using Cox proportional hazards models, adjusting for ag...Continue Reading

Citations

Aug 24, 2012·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Raymond V Oliva, George L Bakris
Sep 18, 2010·European Heart Journal·Sripal BangaloreUNKNOWN Treating to New Targets Steering Committee and Investigators
Jun 24, 2011·European Heart Journal·Peter S Sever, Franz H Messerli
Jul 21, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Laurie A TomlinsonChakravarthi Rajkumar
Aug 13, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Massimo Volpe, Giuliano Tocci
Jan 18, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Jing XuNan Chen
Mar 5, 2011·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Ausilia MaioneGiovanni F M Strippoli
Nov 12, 2010·QJM : Monthly Journal of the Association of Physicians·J I Pérez-CalvoUNKNOWN RICA Investigators
Jul 6, 2014·Nephrology·Nathan A Hewitt, Grahame J Elder
Feb 6, 2016·American Journal of Men's Health·Omer A RaheemTung-Chin Hsieh
Oct 19, 2017·Expert Review of Proteomics·Sarah Röthlisberger, Johanna Pedroza-Diaz
Jul 2, 2017·Journal of the American Heart Association·Anxin WangYilong Wang
May 28, 2011·Stroke; a Journal of Cerebral Circulation·Salvador Cruz-FloresUNKNOWN Council on Quality of Care and Outcomes Research
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Apr 9, 2009·Nature Reviews. Cardiology·Varun AgrawalPeter A McCullough
Nov 30, 2006·Journal of the American Society of Nephrology : JASN·Pablo GomezUNKNOWN FATH Study Group
Oct 28, 2014·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Z LiX Zhao
Jul 12, 2012·International Journal of Clinical Practice·R HajhosseinyD J Goldsmith
Feb 6, 2020·Clinical and Experimental Nephrology·Hiroshi Kawachi, Yoshiyasu Fukusumi
Jun 25, 2013·Journal of Cardiovascular Pharmacology·George Stojan, Michelle Petri
Jul 3, 2019·International Journal of Environmental Research and Public Health·Abu Mohd NaserMatthew O Gribble
Jun 17, 2020·Journal of the American Heart Association·Ahlim Alsanani, Joseph I Shapiro
Sep 8, 2021·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Akira FukuiIssei Komuro
Dec 17, 2021·Yonsei Medical Journal·Sang Min LeeJae-Hong Ryoo

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