Proteinuria and the Clinical Course of Dobrava-Belgrade Hantavirus Infection

Nephron Extra
Markus MeierMartin Nitschke

Abstract

Human infection with Dobrava-Belgrade virus (DOBV) in Northern Germany causes a mild form of hantavirus disease predominantly characterized by acute kidney injury due to interstitial nephritis. We evaluated the largest number of DOBV-infected patients so far regarding clinical course, proteinuria, and prognostic markers. Patients with DOBV-associated hantavirus disease admitted to the Renal Division of the University of Lübeck (Germany) between 1997 and 2012 were included in this study. Symptoms, clinical course, laboratory parameters, and urinary protein analysis were investigated at admission (baseline, t0), 3-5 days (t3-5), 10-17 days (t10-17), and after 1 year of follow-up (t365). Of the 34 patients (male/female ratio: 23/11; age: 41 ± 14 years) included in the study, 4 underwent hemodialysis (HD). Glomerular filtration rate was 17 ± 14 mL/min at t0 and increased to 27 ± 26 mL/min (t3-5), 57 ± 20 mL/min (t10-17), and 84 ± 16 mL/min (t365). Albuminuria and tubular proteinuria (α1- and β2-microglobulin) decreased during follow-up; the urinary α1-microglobulin concentration in patients who required HD was significantly higher than that in patients not requiring HD (t0: 186 ± 51 vs. 45 ± 26 mg/g creatinine; t3-5: 87 ± 14 vs. 32...Continue Reading

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Citations

Mar 28, 2019·The American Journal of Tropical Medicine and Hygiene·Hyun Kuk KimSehrish Jalal
Sep 10, 2020·Frontiers in Cellular and Infection Microbiology·Danny NoackBarry H G Rockx
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Ihor LozynskyiColleen B Jonsson
Jul 17, 2021·International Journal of Infectious Diseases : IJID : Official Publication of the International Society for Infectious Diseases·René LópezUNKNOWN Hantavirus Study Group in Chile

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Methods Mentioned

BETA
electrophoresis
biopsy
enzyme-linked immunosorbent assays
ELISA
biopsies

Software Mentioned

SigmaPlot

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