Proteinuria following sirolimus conversion is associated with deterioration of kidney function in liver transplant recipients

Transplantation
Hani M WadeiThomas A Gonwa

Abstract

The role of sirolimus (SRL) conversion in the preservation of kidney function in liver transplant (LT) recipients with calcineurin inhibitor (CNI) nephrotoxicity is unclear. Data on 102 LT recipients with deteriorating kidney function after CNI exposure who were later converted to SRL were retrospectively reviewed. Kidney function was assessed using serum creatinine and estimated glomerular filtration rate (eGFR) at time of conversion and serially thereafter. The primary endpoint was stabilization or improvement of kidney function as assessed by eGFR at last recorded follow-up compared with eGFR at the time of conversion. After a median (interquartile range) of 3.1 (1.6-4.5) years of follow-up, serum creatinine decreased from 1.9 ± 0.8 to 1.8 ± 0.7 mg/dL (P=0.25) and eGFR increased from 40.8 ± 16.7 to 44.3 ± 20.0 mL/min (P=0.03). During the same time period, 24-hr urinary protein excretion increased from median (interquartile range) of 72 (0-155) to 382 (169-999) mg/day (P=0.0001). Sixty-five (64%) patients achieved the primary endpoint and 37 (36%) experienced deterioration in kidney function. Independent predictors of deterioration of kidney function after SRL conversion were development of proteinuria ≥ 1000 mg/day (odds rat...Continue Reading

References

Dec 1, 1995·Therapeutic Drug Monitoring·S N Sehgal
Jan 28, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Satheesh NairGeorge Loss
Jun 27, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Attaphol PawarodePaul J Thuluvath
Sep 5, 2003·The New England Journal of Medicine·Akinlolu O OjoRobert M Merion
Oct 4, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Kyrsten D FairbanksPaul J Thuluvath
Apr 28, 2004·Clinical Transplantation·Anil S ParameshEnver Akalin
Jun 30, 2005·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Viorica BumbeaLionel Rostaing
Sep 16, 2005·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Hervé SarteletPhilippe Rieu
Nov 12, 2005·The New England Journal of Medicine·Hassane IzzedineCamille Frances
Nov 12, 2005·The New England Journal of Medicine·Robert A Hegele
Jan 24, 2006·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·L Straathof-GalemaL B Hilbrands
Apr 25, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Fritz DiekmannJosep M Campistol
Apr 26, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Isabelle MorardEmiliano Giostra
May 10, 2007·Clinical Transplantation·Mical S CampbellK Rajender Reddy
Aug 21, 2007·Clinical Journal of the American Society of Nephrology : CJASN·Emmanuel LetavernierChristophe Legendre
Nov 30, 2007·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Christopher J E WatsonJ Andrew Bradley
Feb 12, 2008·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A Z AliabadiA O Zuckermann
Apr 25, 2008·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Derek DuBayGeorge Therapondos
Jan 30, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Andrea DiMartini, Kapil Chopra
Oct 31, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Michael R CharltonUNKNOWN International Liver Transplantation Society Expert Panel
Jan 9, 2010·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·A PadiyarJ J Augustine
May 15, 2010·Digestive Diseases and Sciences·Andrew L SamuelsonAijaz Ahmed
Sep 4, 2010·Clinical Journal of the American Society of Nephrology : CJASN·Titte R SrinivasJesse D Schold
Sep 4, 2010·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sumeet K AsraniW Ray Kim
Dec 1, 2010·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Nassim KamarLionel Rostaing
Jul 26, 2011·Clinical Journal of the American Society of Nephrology : CJASN·John C LamattinaArjang Djamali

❮ Previous
Next ❯

Citations

Feb 16, 2013·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Yves Pirson
Apr 11, 2014·Journal of Transplantation·Goran B Klintmalm, Björn Nashan
Oct 20, 2012·Current Opinion in Organ Transplantation·Maxime TouzotJacques Dantal
Dec 17, 2015·Expert Opinion on Drug Safety·Pedro Ventura AguiarFritz Diekmann
Oct 27, 2015·Transplantation·Ana P Rossi, John P Vella
Nov 8, 2012·Pediatric Transplantation·Robyn Greenfield MatloffJeffrey M Saland
May 30, 2013·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·F SalibaUNKNOWN H2304 Study Group
Jan 13, 2018·Clinical Journal of the American Society of Nephrology : CJASN·Karen M Warburton, Alden M Doyle
Jun 2, 2020·Scandinavian Journal of Gastroenterology·Fredrik ÅbergWilliam Bennet
Sep 6, 2020·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Hani M Wadei, Andrew P Keaveny
Jun 9, 2015·World Journal of Hepatology·Maryam MoiniEric M Tichy
Sep 26, 2020·Therapeutic Advances in Musculoskeletal Disease·Liying PengXiaofeng Zeng

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Geoffrey S JensenJ F Trotter
Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society
Derek DuBayGeorge Therapondos
© 2022 Meta ULC. All rights reserved