Proteinuria in diabetic patients--is it always diabetic nephropathy?

Kidney & Blood Pressure Research
Raoul BergnerMichael Uppenkamp

Abstract

Diabetic nephropathy (dNP) is a consequence of type 1 and type 2 diabetes, typically occurring between 5 and 15 years after diabetes has been diagnosed. The coincidence of dNP and diabetic retinopathy (dRP) is well known. In this study we correlated the histological findings of the kidney biopsy with the clinically expected diagnosis of dNP. Over a 4-year period with a total of 326 kidney biopsies, 85 biopsies were performed on patients with diabetes. In all of these patients we had information about duration of diabetes and ophthalmological status. Additionally, data about proteinuria, urine sediment and autoantibodies were available. The nephrologist had to give the suspected diagnosis before the biopsy was performed, using the clinical data available. In 57 patients (67%) dNP was predicted clinically before biopsy. In 28 patients we expected a different kind of kidney disease. Only 43 patients had dNP histologically. In 16 out of 19 patients with dRP we also found dNP. 26 patients with dNP did not have dRP. So dRP was very specific but not sensitive to predict dNP. On the other hand, all patients without dRP but acanthocytes in urine sediment had non-diabetic kidney disease (NDKD). In the case of patients with neither dRP no...Continue Reading

References

Apr 1, 1992·Kidney International·H H ParvingS Larsen
Jun 1, 1995·Diabetic Medicine : a Journal of the British Diabetic Association·E R MathiesenT Deckert
Feb 1, 1993·Journal of the American Society of Nephrology : JASN·V GambaraT Bertani
Dec 1, 1996·Diabetologia·P FiorettoR Nosadini
Feb 12, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S K MakA K Wong
Jan 24, 1998·Journal of the American Society of Nephrology : JASN·R E GilbertG Jerums
Oct 30, 1998·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·M M SchwartzD Batlle
Aug 26, 1999·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·S Olsen
Mar 8, 2000·Diabetes Research and Clinical Practice·M M Campos-PastorM Rigopoulos
Jul 25, 2000·The British Journal of Ophthalmology·E ZanderW Kerner
Sep 30, 2000·Kidney International·P K ChristensenH H Parving
Mar 29, 2002·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Gianna MazzuccoGuido Monga
Sep 6, 2002·Diabetes Research and Clinical Practice·Assumpta SerraJosep Bonet

❮ Previous
Next ❯

Citations

Apr 26, 2011·International Urology and Nephrology·Caroline Jane MagriJosanne Vassallo
Oct 11, 2007·Diabetes, Obesity & Metabolism·Andrew J KrentzChristopher D Byrne
Jun 6, 2014·Nephrology·Jessie TengRichard J MacIsaac
Apr 17, 2008·Journal of Diabetes and Its Complications·Pinar Altiaylik OzerSunay Duman
Jun 21, 2018·Internal and Emergency Medicine·Abhilash KoratalaWilliam L Clapp

❮ Previous
Next ❯

Related Concepts

Related Feeds

Autoimmune Diabetes & Tolerance

Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.