Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis

PloS One
Chih-Hao ChenJiann-Shing Jeng

Abstract

Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis. We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ≥2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis. Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis. Proteinuria is an independent predictor of unfav...Continue Reading

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Citations

Oct 6, 2015·Journal of the Neurological Sciences·Jin-Man JungSungwook Yu
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Related Concepts

Brain Ischemia
Proteinuria
Thrombolytic Therapy
Acute Cerebrovascular Accidents
Atrial Fibrillation
Diabetes Mellitus
Hemorrhage
Hyperlipidemia
Cerebrovascular Accident
Thrombolytic Therapy

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