Proteinuria independently predicts unfavorable outcome of ischemic stroke patients receiving intravenous thrombolysis

PloS One
Chih-Hao ChenJiann-Shing Jeng


Patients with low estimated glomerular filtration rate (eGFR) and proteinuria may be at increased risk for stroke. This study investigated whether low eGFR and proteinuria are outcome predictors in stroke patients treated with intravenous thrombolysis. We studied 432 consecutive stroke patients who received thrombolysis from January 2006 to December 2012, in Taiwan. Unfavorable outcome was defined as modified Rankin scale ≥2 at 3 months after stroke. Proteinuria was classified as negative or trace, mild, and moderate to severe. Using logistic regression analysis, we identified independent factors for unfavorable outcome after thrombolysis. Of all patients, 32.7% had proteinuria. Patients with proteinuria were older, had higher frequencies of diabetes mellitus, hyperlipidemia, atrial fibrillation, lower eGFR, and greater severity of stroke upon admission than those without proteinuria. Proteinuria, not low eGFR, was an independent predictor for unfavorable outcome for stroke (OR = 2.00 for mild proteinuria, p = 0.035; OR = 2.54 for moderate to severe proteinuria, p = 0.035). However, no clear relationship was found between proteinuria and symptomatic hemorrhage after thrombolysis. Proteinuria is an independent predictor of unfav...Continue Reading


Apr 1, 1989·Diabetologia·T DeckertA Kofoed-Enevoldsen
Dec 14, 1995·The New England Journal of Medicine·National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group
Aug 26, 1998·The Canadian Journal of Neurological Sciences. Le Journal Canadien Des Sciences Neurologiques·J W NorrisP Teal
May 5, 2000·The Cochrane Database of Systematic Reviews·J M WardlawT Yamaguchi
Jun 8, 2002·Stroke; a Journal of Cerebral Circulation·Ronald S MacWalterRouling Chen
Feb 1, 2003·BMJ : British Medical Journal·Charles Warlow, J M Wardlaw
Aug 15, 2003·The Cochrane Database of Systematic Reviews·J M WardlawEivind Berge
Sep 24, 2004·The New England Journal of Medicine·Alan S GoChi-yuan Hsu
Jan 25, 2005·Lancet·A Meguid El Nahas, Aminu K Bello
Dec 1, 2005·Kidney International·Meguid El Nahas
Jun 24, 2006·Journal of Cardiovascular Pharmacology·Peter OchodnickyDick de Zeeuw
Jun 15, 2007·Journal of the American College of Cardiology·Keith A A FoxEugene Braunwald
Nov 8, 2007·JAMA : the Journal of the American Medical Association·Josef CoreshAndrew S Levey
Jun 3, 2008·Journal of the Neurological Sciences·Bruce Ovbiagele
Sep 26, 2008·The New England Journal of Medicine·Werner HackeECASS Investigators
Oct 18, 2008·Stroke; a Journal of Cerebral Circulation·Nils WahlgrenSafe Implementation of Thrombolysis in Stroke-MOnitoring STudy Investigators
Dec 17, 2008·American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation·Toshiharu NinomiyaRachel Huxley
Feb 3, 2009·Stroke; a Journal of Cerebral Circulation·Gilad YahalomDavid Tanne
Apr 9, 2009·Nature Reviews. Cardiology·Varun AgrawalPeter A McCullough
Sep 19, 2009·Stroke; a Journal of Cerebral Circulation·Kazunori ToyodaStroke Acute Management with Urgent Risk-factor Assessment and Improvement Study Investigators
Dec 1, 2009·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Varun AgrawalPeter A McCullough
Mar 13, 2010·Stroke; a Journal of Cerebral Circulation·A-Ching ChaoTaiwan Thrombolytic Therapy for Acute Ischemic Stroke (TTT-AIS) Study Group
Jun 18, 2010·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Vijay K SharmaHock L Teoh
Oct 12, 2010·Stroke; a Journal of Cerebral Circulation·Meng LeeBruce Ovbiagele
Feb 7, 2012·Stroke; a Journal of Cerebral Circulation·Gustavo SaposnikStroke Outcomes Research Canada (SORCan) Working Group
May 18, 2012·Neurology·Y KumaiFSR Investigators
Apr 16, 2013·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·B-H ChoK-H Cho


Oct 6, 2015·Journal of the Neurological Sciences·Jin-Man JungSungwook Yu
Jan 13, 2015·Journal of Stroke and Cerebrovascular Diseases : the Official Journal of National Stroke Association·Cheng-Yang HsiehChih-Hung Chen
Nov 20, 2016·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·H GensickeThrombolysis in Stroke Patients (TRISP) Collaborators

Related Concepts

Brain Ischemia
Thrombolytic Therapy
Acute Cerebrovascular Accidents
Atrial Fibrillation
Diabetes Mellitus
Cerebrovascular Accident
Thrombolytic Therapy

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