Proteinuria rebound in IgA nephropathy associated with obesity-related glomerulopathy

CEN Case Reports
Hiro MatsukuraMiho Tatematsu

Abstract

IgA nephropathy (IgAN), the most prevalent primary chronic glomerulonephritis worldwide, has three major risk factors: hypertension, proteinuria >1 g/day, and severe renal lesions. Obesity also portends a poor prognosis. A Japanese boy with IgAN showed nephrotic syndrome at presentation. Pathological features resembled those of membranoproliferative glomerulonephritis (MPGN), although IgA deposition differed from MPGN and IgAN. Combination therapy improved renal lesions, but rebound deterioration of proteinuria occurred in this patient, who had marked obesity and hypertension. Serial kidney biopsy specimens were compatible with obesity-related glomerulopathy (ORG). Rebound proteinuria was apparently attributable to ORG rather than relapse and flaring up of IgAN.

References

Jan 1, 1992·Nephron·N YoshikawaH Nakamura
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Mar 22, 2001·Kidney International·N KambhamV D D'Agati
Jan 9, 2004·Clinical and Experimental Nephrology·Kikuo IitakaOsamu Motoyama
Feb 24, 2006·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Tarak Srivastava
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Nov 27, 2007·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Yohei IkezumiMakoto Uchiyama
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Jan 29, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Norishige YoshikawaUNKNOWN Japanese Pediatric IgA Nephropathy Treatment Study Group
Oct 23, 2008·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Susan M FowlerTracy E Hunley
Jun 21, 2013·The New England Journal of Medicine·Robert J Wyatt, Bruce A Julian
Dec 10, 2014·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Koichi KameiUNKNOWN Japanese Pediatric IgA Nephropathy Treatment Group

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