Proteoglycan gene expression in rat liver after partial hepatectomy

Biochemical and Biophysical Research Communications
M GallaiSnorri S Thorgeirsson

Abstract

Liver regeneration is regulated by several factors. Among these extracellular matrix plays a crucial role in the restoration of normal structure. Proteoglycans are major components of extracellular matrix and they are able to bind growth factors implicated in liver growth. We studied syndecan, perlecan, fibroglycan, and decorin expression after partial hepatectomy in rats by Northern blot analysis. A strong early upregulation was observed at 30 min in decorin expression which was followed by the first syndecan and perlecan peaks at 2 and 4 hours after hepatectomy. At 24 hours, which is the peak of hepatocyte DNA synthesis, all these three proteoglycans had elevated steady state transcript level. Fibroglycan message decreased after partial hepatectomy and remained low during the experimental period. The different expression pattern of the proteoglycans suggests that these extracellular matrix components may selectively influence the regeneration process.

Citations

Nov 15, 2006·Gastroenterology·Xinping TanSatdarshan P S Monga
Apr 4, 2007·Liver International : Official Journal of the International Association for the Study of the Liver·Víctor CortésAttilio Rigotti
Apr 5, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Kari N Nejak-BowenGeorge K Michalopoulos
Dec 19, 2009·The American Journal of Pathology·George K Michalopoulos
Aug 11, 2015·Liver International : Official Journal of the International Association for the Study of the Liver·Peri KocabayogluScott L Friedman
Nov 7, 2008·Journal of Hepato-biliary-pancreatic Surgery·Akitoshi KimuraMutsuo Sasaki
Jun 27, 2014·Expert Review of Gastroenterology & Hepatology·George K Michalopoulos
Sep 7, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Salman R KhetaniSangeeta N Bhatia
Jun 15, 2007·Journal of Cellular Physiology·George K Michalopoulos
Aug 9, 2020·Nature Reviews. Gastroenterology & Hepatology·George K Michalopoulos, Bharat Bhushan
Jan 24, 2021·Gene Expression·Nicole MartucciWendy M Mars

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