Proteoglycans in Normal and Healing Skin

Advances in Wound Care
Margaret Mary Smith, James Melrose

Abstract

Significance: Proteoglycans have a distinct spatial localization in normal skin and are essential for the correct structural development, organization, hydration, and functional properties of this tissue. The extracellular matrix (ECM) is no longer considered to be just an inert supportive material but is a source of directive, spatial and temporal, contextual information to the cells via components such as the proteoglycans. There is a pressing need to improve our understanding of how these important molecules functionally interact with other matrix structures, cells and cellular mediators in normal skin and during wound healing. Recent Advances: New antibodies to glycosaminoglycan side chain components of skin proteoglycans have facilitated the elucidation of detailed localization patterns within skin. Other studies have revealed important proliferative activities of proteinase-generated fragments of proteoglycans and other ECM components (matricryptins). Knockout mice have further established the functional importance of skin proteoglycans in the assembly and homeostasis of the normal skin ECM. Critical Issues: Our comprehension of the molecular and structural complexity of skin as a complex, dynamic, constantly renewing, la...Continue Reading

References

Jan 1, 1992·Annual Review of Cell Biology·M BernfieldE J Lose
Oct 1, 1992·Clinical and Experimental Immunology·P J O'ConnellA J d'Apice
Aug 1, 1992·The Journal of Experimental Medicine·M S SyI Stamenkovic
Jul 1, 1991·The Journal of Cell Biology·A NishiyamaW B Stallcup
Feb 1, 1991·Journal of Structural Biology·R FleischmajerJ D Termine
Mar 1, 1989·The Journal of Investigative Dermatology·R TammiM Tammi
Aug 1, 1988·The Journal of Investigative Dermatology·E Schwartz
May 1, 1970·The Histochemical Journal·F T Zugibe
Feb 1, 1995·The Journal of Dermatology·N YasakaK Tamaki
Oct 27, 1995·The Journal of Biological Chemistry·E BengtssonY Sommarin
Feb 1, 1994·International Journal of Dermatology·I GhersetichG Dini
Jan 1, 1994·Annals of Surgery·M T LongakerN S Adzick
Aug 19, 1993·Biochimica Et Biophysica Acta·P AntonssonA Oldberg
Jun 1, 1993·Journal of Cutaneous Pathology·N S Penneys
Aug 1, 1993·Photochemistry and Photobiology·D MargelinJ Picard
Sep 1, 1995·Journal of Dermatological Science·H F RuloD J Ruiter
Apr 19, 1996·The Journal of Biological Chemistry·L M CorpuzG W Conrad
Oct 18, 1996·The Journal of Biological Chemistry·M A BurgW B Stallcup
Aug 1, 1996·The British Journal of Dermatology·E F BernsteinJ Uitto
Sep 1, 1996·Osteoarthritis and Cartilage·P J RoughleyJ S Mort
Feb 10, 1997·The Journal of Cell Biology·K G DanielsonR V Iozzo
Jun 17, 1998·Matrix Biology : Journal of the International Society for Matrix Biology·A M HockingD J McQuillan
May 7, 1999·Wound Repair and Regeneration : Official Publication of the Wound Healing Society [and] the European Tissue Repair Society·W Y Chen, G Abatangelo
Jul 10, 1999·The Journal of Biological Chemistry·A AspbergD Heinegård
Feb 26, 2000·Histopathology·K SayaniP G Scott
Mar 1, 2000·Molecular Pathology : MP·S GoodisonD Tarin
Mar 21, 2000·Molecular and Cellular Biochemistry·E M KoźmaR Bobiński
Apr 5, 2000·Pathology Oncology Research : POR·V YasaseverN Dalay

❮ Previous
Next ❯

Citations

Jul 7, 2016·Acta Biomaterialia·Subhamoy DasAaron B Baker
Nov 9, 2016·Plastic and Reconstructive Surgery. Global Open·Anouska DasguptaWilliam W Li
Mar 30, 2017·Applied Biochemistry and Biotechnology·Thiago B CahúRanilson S Bezerra
Mar 3, 2019·Journal of Cellular Biochemistry·Eliezer SidonDafna Benayahu
Mar 21, 2019·Dermatologic Surgery : Official Publication for American Society for Dermatologic Surgery [et Al.]·Noelani González, David J Goldberg
Jun 30, 2019·The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology·Douglas R Keene, Sara F Tufa
Nov 30, 2018·Current Drug Targets·Irene Anton-SalesDana Kralisch
Jan 30, 2020·Advances in Wound Care·Michael J BlairKyle P Quinn
Jun 20, 2020·Expert Review of Proteomics·Jörn DengjelAlexander Nyström
Apr 12, 2019·International Journal of Molecular Sciences·Sandra Fernández-MartosJesús Espada
Jun 21, 2019·Cells·Alexandra L RippaEkaterina A Vorotelyak
Feb 6, 2017·Journal of Cosmetic and Laser Therapy : Official Publication of the European Society for Laser Dermatology·Clara BarbaLuisa Coderch
Feb 18, 2020·Frontiers in Pharmacology·Xiaoxiao PangZhong Zheng
Jun 1, 2017·Tissue Engineering. Part a·Alaa MansourFaleh Tamimi
Mar 22, 2020·BMC Veterinary Research·Rosanna MarsellaLluís Ferrer
Jun 17, 2020·Disease Models & Mechanisms·Michelle F GriffinMichael T Longaker
Feb 12, 2021·Journal of Clinical Medicine·María I Quiñones-VicoSalvador Arias-Santiago
Feb 12, 2021·Biomedical Materials·Laura Mihaela StefanOana Craciunescu
Mar 2, 2021·Frontiers in Immunology·Nathalie Boulanger, Stephen Wikel
Feb 6, 2021·Matrix Biology Plus·Yaqing Huang, Themis R Kyriakides
Jun 8, 2021·Journal of Oral Biology and Craniofacial Research·Dominic AugustineShankargouda Patil
Dec 16, 2020·ACS Biomaterials Science & Engineering·Binghui LiuLing Leng

❮ Previous
Next ❯

Methods Mentioned

BETA
electron microscopy
electrophoresis
glycosylation
biopsies

Software Mentioned

Biglycan
Decorunt

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Comparative Biochemistry and Physiology. Part B, Biochemistry & Molecular Biology
B LathaM Babu
Seikagaku. The Journal of Japanese Biochemical Society
T MuramatsuK Uchimura
The Anatomical Record : Advances in Integrative Anatomy and Evolutionary Biology
Dianhua JiangPaul W Noble
Advances in Wound Care
Natasa StrboOlivera Stojadinovic
© 2021 Meta ULC. All rights reserved