Proteoglycans in Obesity-Associated Metabolic Dysfunction and Meta-Inflammation.

Frontiers in Immunology
Ariane R PessentheinerPhilip L S M Gordts

Abstract

Proteoglycans are a specific subset of glycoproteins found at the cell surface and in the extracellular matrix, where they interact with a plethora of proteins involved in metabolic homeostasis and meta-inflammation. Over the last decade, new insights have emerged on the mechanism and biological significance of these interactions in the context of diet-induced disorders such as obesity and type-2 diabetes. Complications of energy metabolism drive most diet-induced metabolic disorders, which results in low-grade chronic inflammation, thereby affecting proper function of many vital organs involved in energy homeostasis, such as the brain, liver, kidney, heart and adipose tissue. Here, we discuss how heparan, chondroitin and keratan sulfate proteoglycans modulate obesity-induced metabolic dysfunction and low-grade inflammation that impact the initiation and progression of obesity-associated morbidities.

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Citations

Sep 25, 2020·Critical Reviews in Food Science and Nutrition·Luigi BarreaGiovanna Muscogiuri
Aug 6, 2020·International Journal of Molecular Sciences·Álvaro González-DomínguezAlfonso María Lechuga-Sancho
Feb 6, 2021·International Journal of Molecular Sciences·Sebastian Dommel, Matthias Blüher
Apr 2, 2021·Seminars in Thrombosis and Hemostasis·Linda M Hiebert
May 25, 2021·World Journal of Gastroenterology : WJG·Shun TakayamaYuji Naito
Jun 3, 2021·International Journal of Molecular Sciences·Anett HudákTamás Letoha
Jun 11, 2021·Expert Review of Proteomics·Flaminia BardanzelluVassilios Fanos
Nov 10, 2021·Journal of Cellular Physiology·Pan MiaoSun Chao
Dec 5, 2021·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Heidi N du PreezJohnson Lin
May 30, 2021·Phlebology·Karen L HerbstEthan Larson

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Methods Mentioned

BETA
dissect
antisense oligonucleotides
SGBS
transgenic
biopsies
glycosylation

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