Proteolytic activities that mediate apoptosis

Annual Review of Physiology
V J Kidd

Abstract

Since the discovery that cells can activate their own suicide program, investigators have attempted to determine whether the events that are associated with this form of cell death are genetically determined. The discovery that the ced-3 gene of Caenorhabditis elegans encodes a cysteine protease essential for developmentally regulated apoptosis ignited interest in this area of research. As a result, we now know that cell death is specified by a number of genes and that this biologic process contributes significantly to development, tumorigenesis, and autoimmune disease. In this review I summarize what is currently known about signaling pathways involved in apoptosis, with particular emphasis on the function of the cysteine proteases known as caspases. However, there is also evidence that protease-independent cell death pathways exist. Is there a relationship between these two distinct mechanisms? If so, how do they communicate? Finally, even though the involvement of tumor necrosis factor/nerve growth factor family of receptors and cysteine proteases has been elegantly established as a component of many apoptotic signaling pathways, what happens downstream of these initial events? Why are only a selected group of cellular prote...Continue Reading

References

Mar 1, 1977·Developmental Biology·J E Sulston, H R Horvitz
Sep 1, 1992·Cancer Metastasis Reviews·J A Hickman
Oct 8, 1992·Nature·R P BissonnetteD R Green
Dec 1, 1992·Toxicology Letters·J A HickmanR Parmar
Apr 3, 1992·Cell·G I EvanD C Hancock
Apr 1, 1992·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·L E Gerschenson, R J Rotello
Jun 1, 1992·Leukemia Research·S SadullahD G Oscier
Jan 1, 1991·Annual Review of Immunology·P L Cohen, R A Eisenberg
Jan 1, 1991·Annual Review of Neuroscience·R W Oppenheim
Aug 1, 1991·Molecular and Cellular Biology·G P OwensJ J Cohen
May 18, 1990·Cell·S Moreno, P Nurse
Nov 4, 1966·Science·J W Saunders
Jan 1, 1980·International Review of Cytology·A H WyllieA R Currie
Nov 17, 1995·Science·T S GriffithT A Ferguson
Oct 22, 1993·Cell·D M HockenberyS J Korsmeyer
Oct 1, 1994·The Journal of Cell Biology·K Schulze-OsthoffP H Krammer
Jan 1, 1995·Molecular and Cellular Biology·J M LahtiV J Kidd
Mar 24, 1995·The Journal of Biological Chemistry·S J MartinD R Green
May 1, 1995·The Journal of Experimental Medicine·H NakajimaP A Henkart

❮ Previous
Next ❯

Citations

Feb 9, 2002·Journal of Biomedical Materials Research·Matthew S ShiveJames M Anderson
Dec 9, 2000·Biochemical and Biophysical Research Communications·G R Akkaraju, A Basu
Apr 1, 2008·Journal of Biosciences·Feng LiuYu-Yang Jiang
Sep 3, 2003·Biochemical and Biophysical Research Communications·Jung-Ae KimYong Soo Lee
Jan 5, 2002·European Journal of Pharmacology·V Y WongD P Brooks
Sep 2, 1999·Advances in Enzyme Regulation·F M Hughes, J A Cidlowski
Jun 1, 2000·Advances in Enzyme Regulation·E G Krebs, J D Graves
Oct 8, 1999·Developmental and Comparative Immunology·M M Compton, J K Wickliffe
Apr 11, 2001·Journal of Controlled Release : Official Journal of the Controlled Release Society·T MinkoJ Kopecek
Nov 20, 1998·Trends in Genetics : TIG·M M MetzsteinH R Horvitz
Jan 17, 2002·Neurochemistry International·Laura ColombaioniMercedes Garcia-Gil
Dec 31, 1998·Free Radical Biology & Medicine·L VirágC Szabó
Oct 8, 1999·Trends in Endocrinology and Metabolism : TEM·E B Thompson
Jan 18, 2003·Biochimica Et Biophysica Acta·Patrick Williamson, Robert A Schlegel
Apr 27, 1999·Biochimica Et Biophysica Acta·T Levade, J P Jaffrézou
May 16, 2009·Cancer Gene Therapy·I EchchgaddaS Bose
Mar 29, 2000·Journal of Gastroenterology and Hepatology·A RamachandranK A Balasubramanian
Mar 10, 2001·Journal of Neurochemistry·L C EdsallS Milstien
Apr 30, 2008·Nutrition and Cancer·Sahdeo PrasadYogeshwer Shukla

❮ Previous
Next ❯

Methods Mentioned

BETA
ICE
two-hybrid
transfection
environmental stress
GTPases
GTPase
NMR
nuclear translocation

Related Concepts

Related Feeds

Autoimmune Diseases

Autoimmune diseases occur as a result of an attack by the immune system on the body’s own tissues resulting in damage and dysfunction. There are different types of autoimmune diseases, in which there is a complex and unknown interaction between genetics and the environment. Discover the latest research on autoimmune diseases here.

Apoptotic Caspases

Apoptotic caspases belong to the protease enzyme family and are known to play an essential role in inflammation and programmed cell death. Here is the latest research.

Apoptosis in Cancer

Apoptosis is an important mechanism in cancer. By evading apoptosis, tumors can continue to grow without regulation and metastasize systemically. Many therapies are evaluating the use of pro-apoptotic activation to eliminate cancer growth. Here is the latest research on apoptosis in cancer.

Apoptosis

Apoptosis is a specific process that leads to programmed cell death through the activation of an evolutionary conserved intracellular pathway leading to pathognomic cellular changes distinct from cellular necrosis