PMID: 7029766Nov 1, 1981Paper

Proteolytic activity of blowfly larvae secretions in experimental burns

Surgery
L M VistnesG A Ksander

Abstract

Secretions of larvae of the blowfly Calliphora erythrocephala digested experimental rat skin burn eschar in vivo and in vitro when applied topically in a vanishing cream base. Debridement was characterized by de-epithelialization and digestion of dermal collagen to a subfollicular level over a 3-day period. Analytic investigation of the secretions demonstrated the presence of enzymes with activities characteristic of trypsin, leucine aminopeptidase, and carboxypeptidases A and B. These were partially characterized. There was no evidence of chymotrypsin, elastase, or collagenase. Preparation of a suitable therapeutic form could result in a preparation useful for enzymatic debridement.

Citations

Oct 17, 2008·Clinical Orthopaedics and Related Research·Gwendolyn CazanderGerrolt N Jukema
Sep 16, 1999·International Journal of Dermatology·K Y MumcuogluI Raz
Apr 1, 1985·The Western Journal of Medicine·J BunkisR L Walton
Feb 23, 2007·International Journal of Clinical Practice·A Parnés, K M Lagan
Jul 18, 2002·Journal of the American Podiatric Medical Association·David G ArmstrongAndrew J M Boulton

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