PMID: 2419893Jan 1, 1986

Proteolytic complex from Aspergillus terricola (review)

Prikladnaia biokhimiia i mikrobiologiia
A A Selezneva, M D Bol'shakova


Results are presented of the studies on the proteolytic enzymes produced by the fungus Aspergillus terricola that comprise the antiinflammatory drug Terrilytin. Terrilytin was shown to be a complex of three proteolytic enzymes that contained amylase as well. Two of the proteases (proteases I and II) were of the group of serine proteases by their physico-chemical and enzymatic characteristics and might be considered as two types of the same enzyme. Protease III showed characteristics specific for metalloproteases of the microbial origin, its activity being exhibited in case of the zinc ion presence. Fibrinolytic properties of Terrilytin are associated with the ability of all the three proteases to hydrolyze fibrin and fibrinogen.

Related Concepts

Fibrin Measurement
Fibrinogen Assay
Anti-Inflammatory Agents
Peptide Hydrolases
Proteolytic enzymes for treatment of wounds and ulcers
Proteolytic Enzyme
Serine Endopeptidases
Amylase Measurement

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