PMID: 8977345Aug 1, 1996Paper

Proteolytic degradation of intestinal mucosal extracellular matrix after lamina propria T cell activation

Gut
S L PenderThomas T MacDonald

Abstract

Proteoglycans, consisting of glycosaminoglycan (GAG) side chains covalently linked to a protein core, are a major component of the extracellular matrix of the intestinal lamina propria. This study investigated the effects of lamina propria T cell activation on the proteoglycan component of the matrix. The high degree of sulphation of GAGs means that they are polyanionic and thus can be visualised in tissue sections by means of colloidal-gold labelled cationic probes. In human fetal small intestine there is a dense meshwork of anionic residues in the lamina propria and basement membrane. When explants of human fetal small intestine are cultured ex vivo, and resident lamina propria T cells are activated with pokeweed mitogen, mucosal destruction occurs within three days. This is associated with the rapid loss of anionic sites from the lamina propria. Dermatan sulphate proteoglycan is lost from the tissue and is present at increased concentrations in the organ culture supernatants, indicating that T cell activation has led to solubilisation of lamina propria proteoglycans. Tissue destruction and loss of anionic residues are inhibited in a dose dependent fashion by dexamethasone, and by the protease inhibitor, alpha 2 macroglobulin...Continue Reading

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Citations

Oct 15, 2011·Digestive Diseases and Sciences·Anna Kofla-DlubaczBarbara Iwanczak
Aug 1, 1997·Journal of Pediatric Gastroenterology and Nutrition·S H Murch
Jun 26, 2002·Journal of Pediatric Gastroenterology and Nutrition·Thomas T MacDonald
May 20, 1998·Inflammatory Bowel Diseases·T T MacDonald, S L Pender
Apr 1, 1997·Immunological Reviews·A M Mowat, J L Viney
Jul 23, 1999·Annals of the New York Academy of Sciences·S L PenderT T MacDonald
May 19, 2012·Nutrients·Gianna FerrettiLetizia Saturni
Jun 19, 2013·Autoimmunity Reviews·Alessandra GeremiaAntonio Di Sabatino
Mar 20, 2012·Cell and Tissue Research·Paolo BiancheriThomas T MacDonald
Nov 15, 2005·Journal of Molecular Medicine : Official Organ of the Gesellschaft Deutscher Naturforscher Und Ärzte·Daniela De StefanoRosa Carnuccio
May 5, 2007·European Journal of Pharmacology·Daniela De StefanoRosa Carnuccio
Sep 17, 2003·International Journal of Experimental Pathology·Andrew M VeitchThomas T MacDonald
Nov 26, 1999·JPEN. Journal of Parenteral and Enteral Nutrition·D GanessunkerS M Donovan
Dec 21, 2004·Laboratory Investigation; a Journal of Technical Methods and Pathology·Rachele CiccocioppoDetlef Schuppan
Jun 21, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Giuseppe TerrazzanoEnnio Carbone
Oct 29, 2000·American Journal of Physiology. Gastrointestinal and Liver Physiology·S L PenderT T MacDonald
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Nov 6, 2007·The Journal of Immunology : Official Journal of the American Association of Immunologists·Feng Wu, Shukti Chakravarti
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Feb 4, 1998·Baillière's Clinical Gastroenterology·S H Murch

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