Proteolytic roles of matrix metalloproteinase (MMP)-13 during progression of chronic periodontitis: initial evidence for MMP-13/MMP-9 activation cascade

Journal of Clinical Periodontology
Marcela Hernández RíosJorge Gamonal

Abstract

Matrix metalloproteinases (MMP)-13 can initiate bone resorption and activate proMMP-9 in vitro, and both these MMPs have been widely implicated in tissue destruction associated with chronic periodontitis. We studied whether MMP-13 activity and TIMP-1 levels in gingival crevicular fluid (GCF) associated with progression of chronic periodontitis assessed clinically and by measuring carboxy-terminal telopeptide of collagen I (ICTP) levels. We additionally addressed whether MMP-13 could potentiate gelatinase activation in diseased gingival tissue. In this prospective study, GCF samples from subjects undergoing clinical progression of chronic periodontitis and healthy controls were screened for ICTP levels, MMP-13 activity and TIMP-1. Diseased gingival explants were cultured, treated or not with MMP-13 with or without adding CL-82198, a synthetic MMP-13 selective inhibitor, and assayed by gelatin zymography and densitometric analysis. Active sites demonstrated increased ICTP levels and MMP-13 activity (p<0.05) in progression subjects. The MMP-9 activation rate was elevated in MMP-13-treated explants (p<0.05) and MMP-13 inhibitor prevented MMP-9 activation. MMP-13 could be implicated in the degradation of soft and hard supporting tis...Continue Reading

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Citations

Jan 10, 2013·Arthritis Research & Therapy·Meina WangDi Chen
Oct 29, 2011·Breast Cancer Research : BCR·Eliana PivettaPaola Spessotto
Aug 29, 2014·DNA and Cell Biology·Nam E JooYvonne L Kapila
Jun 29, 2011·Journal of Clinical Periodontology·Timo SorsaMarcela Hernandez
Feb 26, 2011·Journal of Clinical Periodontology·Nurcan Buduneli, Denis F Kinane
Oct 20, 2012·Journal of Clinical Periodontology·Ulvi K GursoyTimo Sorsa
Apr 19, 2015·Developmental Biology·Narudo KawaiYasunori Sasakura
Dec 23, 2016·Journal of Clinical Periodontology·Anna LundmarkTülay Yucel-Lindberg
Jul 30, 2015·Journal of Applied Oral Science : Revista FOB·Nora SilvaJorge Gamonal
Apr 8, 2011·Journal of Dental Research·M HernándezJ Gamonal
Jul 16, 2013·Oral Diseases·G SapnaK Bagri-Manjrekar
Feb 22, 2017·International Journal of Molecular Sciences·Cavalla FrancoHernández Marcela
Jun 9, 2016·Medical Science Monitor : International Medical Journal of Experimental and Clinical Research·Nian LiuGuangxun Zhu
May 11, 2018·Clinical and Experimental Dental Research·Eunice VirtanenBirgitta Söder
Sep 13, 2017·Journal of Periodontal Research·E F de MoraisR A Freitas
Jul 12, 2020·International Journal of Environmental Research and Public Health·Vittorio ChecchiAnnalisa Mazzoni
Nov 23, 2017·Frontiers in Physiology·Patricia Hernández-RíosMarcela Hernández
Jun 4, 2020·Journal of Molecular Histology·Gisela Rodrigues da Silva SassoManoel João Batista Castello Girão
Feb 12, 2021·Haematologica·Tetsuro YokokawaYasuchika Takeishi
Jan 23, 2021·Journal of Personalized Medicine·Yu Gyung KimDo-Yeon Kim

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