Proteome analysis of the causative agent of Chagas disease: Trypanosoma cruzi

International Journal for Parasitology
A Parodi-TaliceC Robello

Abstract

Trypanosoma cruzi, the causative agent of Chagas disease, has evolved particular mechanisms of gene regulation. Gene expression is regulated firstly at post-transcriptional level. This feature makes proteomic methods a promising tool for studying adaptative changes in these parasites. In this work we generated a reproducible method for protein analysis by two-dimensional electrophoresis coupled to mass spectrometry, and a protein map for T. cruzi. Western-blot analysis supported the identity of some of the proteins. This work points to proteomic approach as a powerful tool to study differential expression, stress response or drug resistance in T. cruzi.

References

Jan 1, 1988·Memórias do Instituto Oswaldo Cruz·V T ContrerasS Goldenberg
Nov 24, 1999·Analytical Chemistry·W HancockE Pungor
May 4, 2001·International Journal for Parasitology·W M DegraveM Aslett
Mar 9, 2002·Science·F Ulrich Hartl, Manajit Hayer-Hartl
Nov 6, 2002·The Journal of Experimental Medicine·Bruno Kilunga KubataYoshihiro Urade
Mar 14, 2003·Nature·Mike Tyers, Matthias Mann
Mar 20, 2003·Molecular & Cellular Proteomics : MCP·Jolyne DrummelsmithMarc Ouellette
Apr 15, 2003·Nature Biotechnology·Christine C WuJohn R Yates
Oct 29, 2003·Trends in Parasitology·Julio A Urbina, Roberto Docampo
Dec 19, 2003·Nucleic Acids Research·Michael LuchtanJessica C Kissinger

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Citations

Nov 10, 2010·Proceedings of the National Academy of Sciences of the United States of America·Jenny TelleriaMichel Tibayrenc
Oct 20, 2011·Biotechnology for Biofuels·Wagner R de SouzaGustavo H Goldman
Mar 19, 2014·Experimental Parasitology·Andrea TrochineCarlos Robello
Jan 31, 2012·Journal of Biomedicine & Biotechnology·Deyanira Pérez-MoralesBertha Espinoza
Nov 13, 2008·Archives of Microbiology·Cátia Lacerda SodréOctavio Fernandes
Jul 15, 2005·Expert Review of Molecular Diagnostics·Jorge A Huete-PérezConor R Caffrey
Dec 24, 2014·Journal of Proteomics·Giselle Villa Flor BrunoroRubem Figueiredo Sadok Menna-Barreto
Jun 23, 2010·Experimental Parasitology·Simone A KikuchiOctavio Fernandes
Jan 9, 2010·Journal of Proteomics·Patricia CuervoJose B De Jesus
Mar 28, 2009·Experimental Parasitology·Robert F L Steuart
Oct 26, 2007·Journal of Mass Spectrometry : JMS·A Parodi-TaliceC Robello
Oct 12, 2018·PloS One·Agenor de Castro Moreira Dos Santos JúniorBeatriz Dolabela de Lima
Sep 17, 2020·Revista Da Sociedade Brasileira De Medicina Tropical·Taciana de Souza BayãoRodrigo Siqueira-Batista
Nov 25, 2019·Free Radical Biology & Medicine·Ana Cristina Souza BombaçaRubem Figueiredo Sadok Menna-Barreto
Jan 23, 2021·RSC Medicinal Chemistry·Anutthaman Parthasarathy, Karunakaran Kalesh
Feb 10, 2021·Biochimica Et Biophysica Acta. Proteins and Proteomics·Agenor de Castro Moreira Dos Santos JúniorCarlos André Ornelas Ricart
Apr 26, 2008·Journal of Proteome Research·Hélida M AndradeAlvaro J Romanha
Jun 26, 2021·Chemical Record : an Official Publication of the Chemical Society of Japan ... [et Al.]·Gleiston G DiasEufrânio N da Silva Júnior

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