Proteome analysis to study signal transduction of G protein-coupled receptors

Pharmacology & Therapeutics
Franka PluderAnnette G Beck-Sickinger

Abstract

G protein-coupled receptors (GPCR) play an important role in drug development. Although many classical signal transduction pathways have been elucidated, more and more cross-talk to other cascades, e.g. MAP-kinase have been reported. In order to identify the overall function of receptor stimulation in a specific cell type or under certain conditions proteome analysis has been shown to be a very successful and powerful approach. Here, we will summarize the current state of the art of proteome analysis applied to GPCR.

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Jul 15, 2011·Analytical and Bioanalytical Chemistry·Jeroen KoolWilfried M A Niessen
Apr 3, 2012·Bioinformatics·Bin LiAnd Xuming He
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May 22, 2008·British Journal of Pharmacology·R JockersP Delagrange
Nov 28, 2012·Proteomics. Clinical Applications·Sonja Hess

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