Proteome-wide analysis reveals clues of complementary interactions between mRNAs and their cognate proteins as the physicochemical foundation of the genetic code

RNA Biology
Anton A PolyanskyBojan Zagrovic

Abstract

Despite more than 50 years of effort, the origin of the genetic code remains enigmatic. Among different theories, the stereochemical hypothesis suggests that the code evolved as a consequence of direct interactions between amino acids and appropriate bases. If indeed true, such physicochemical foundation of the mRNA/protein relationship could also potentially lead to novel principles of protein-mRNA interactions in general. Inspired by this promise, we have recently explored the connection between the physicochemical properties of mRNAs and their cognate proteins at the proteome level. Using experimentally and computationally derived measures of solubility of amino acids in aqueous solutions of pyrimidine analogs together with knowledge-based interaction preferences of amino acids for different nucleobases, we have revealed a statistically significant matching between the composition of mRNA coding sequences and the base-binding preferences of their cognate protein sequences. Our findings provide strong support for the stereochemical hypothesis of genetic code's origin and suggest the possibility of direct complementary interactions between mRNAs and cognate proteins even in present-day cells.

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Citations

Feb 28, 2014·RNA Biology·Bojan Zagrovic
Feb 28, 2014·RNA Biology·Sahotra Sarkar
Apr 6, 2017·Journal of Molecular Evolution·Wim Hordijk
Jul 30, 2015·Physical Chemistry Chemical Physics : PCCP·Matea HajnicBojan Zagrovic
Jul 28, 2017·PLoS Computational Biology·Lukas Bartonek, Bojan Zagrovic
Mar 11, 2015·Nucleic Acids Research·Mario Hlevnjak, Bojan Zagrovic
Aug 31, 2017·Annual Review of Genetics·Eugene V Koonin, Artem S Novozhilov
Jun 1, 2018·FEBS Letters·Bojan ZagrovicAnton A Polyansky
Jan 19, 2018·Journal of Molecular Evolution·Gregory A BabbittAndré O Hudson
Aug 27, 2016·The EMBO Journal·Javier Martinez, Bojan Zagrovic
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Jul 1, 2018·Journal of Molecular Evolution·Shubham Tripathi, Michael W Deem
Jan 25, 2021·Journal of Molecular Evolution·Michael Yarus
Aug 3, 2017·Journal of Chemical Theory and Computation·Anita de RuiterBojan Zagrovic

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Methods Mentioned

BETA
X-ray
NMR
fluorescence correlation spectroscopy

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