Proteomic analysis of differential protein expression in neuropathic pain and electroacupuncture treatment models

Proteomics
Ho Joong SungJesang Ko

Abstract

Acupuncture has long been used for pain relief. Although recent studies have shown that acupuncture can reduce neuropathic pain, the mechanism of this effect is not clear and little information is available regarding proteins that are involved in the development of neuropathic pain and the effects of acupuncture. We have developed an animal model for neuropathic pain using young adult male Sprague-Dawley rats. The model was confirmed by behavioral tests. Electroacupuncture (EA) treatment was applied to Zusanli (ST36) of neuropathic pain model to examine the analgesic effect of EA. The protein expression profile of the hypothalamus in both neuropathic pain and EA treatment models was analyzed using two-dimensional electrophoresis-based proteomics. We detected thirty-six proteins that were differentially expressed in the neuropathic pain model compared with normal rats and that restored to normal expression levels after EA treatment. Twenty-one of these proteins were identified in the MS-FiT database and are involved in a number of biological processes, including inflammation, enzyme metabolism and signal transduction. Potential applications of our results include the identification and characterization of signaling pathways invo...Continue Reading

Citations

Jan 12, 2008·The American Journal of Chinese Medicine·William Chi-Shing Cho
Aug 20, 2008·The American Journal of Chinese Medicine·Jaung-Geng Lin, Wei-Liang Chen
Feb 21, 2006·NeuroRx : the Journal of the American Society for Experimental NeuroTherapeutics·Orest Hurko, John L Ryan
Aug 19, 2011·Zhong xi yi jie he xue bao = Journal of Chinese integrative medicine·Lin-na Yu, Jian Pei
Dec 19, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Junwei FangYongyu Zhang
Nov 3, 2012·Evidence-based Complementary and Alternative Medicine : ECAM·Li-Ling LinHsueh-Fen Juan
Sep 28, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Guangli YanXijun Wang
Jan 11, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Yu-Dong XuYong-Qing Yang
Dec 26, 2006·Expert Review of Medical Devices·Sabine M Sator-Katzenschlager, Andrea Michalek-Sauberer
May 7, 2013·Complementary Therapies in Medicine·Aihua ZhangXijun Wang
Mar 24, 2006·Electrophoresis·Michael Fountoulakis, Sophia Kossida
Jan 20, 2006·Journal of Internal Medicine·E Ernst
May 1, 2008·Proteomics. Clinical Applications·Nicolas BousetteThomas Kislinger
Aug 29, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Giovanna FranconiNicola Robinson
Jun 30, 2006·Yonsei Medical Journal·Myeoung Hoon ChaBae Hwan Lee

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