Proteomic analysis of mature melanosomes from the retinal pigmented epithelium

Journal of Proteome Research
Sassan M AzarianDavid S Williams

Abstract

The protein content of melanosomes in the retinal pigment epithelium (RPE) was analyzed by mass spectrometry. More than 100 proteins were found to be common to two out of three variations of sample preparation. Some proteins normally associated with other organelles were detected. Several lysosomal enzymes were detected, with the presence of cathepsin D confirmed by immunoelectron microscopy, thus supporting the previously suggested notion that melanosomes may contribute to the degradation of ingested photoreceptor outer segment disks.

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Citations

Apr 25, 2013·Visual Neuroscience·Laura S FrostKathleen Boesze-Battaglia
Apr 26, 2008·Molecular & Cellular Proteomics : MCP·Kwok-Peng NgJohn W Crabb
Jul 25, 2007·Photochemistry and Photobiology·Janice M BurkeTadeusz Sarna
Jul 23, 2014·PloS One·Antonia E G BoothMiguel C Seabra
Mar 14, 2007·Cell Motility and the Cytoskeleton·Adriana E KlompDavid S Williams
May 23, 2007·Pigment Cell Research·Evelyne Coudrier
May 1, 2008·Proteomics. Clinical Applications·Lorna M Cryan, Colm O'Brien
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Mar 7, 2014·Proteomics. Clinical Applications·Fabrizio CecilianiCristina Lecchi
Apr 27, 2016·Medicinal Research Reviews·Chiara VidoniCiro Isidoro
Sep 26, 2019·Scientific Reports·Laura HellinenMika Reinisalo
Feb 28, 2020·Progress in Retinal and Eye Research·Aparna LakkarajuDavid S Williams

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