Proteomic analysis of mice hippocampus in simulated microgravity environment

Journal of Proteome Research
Poonam SarkarGovindarajan T Ramesh

Abstract

Space travel induces many deleterious effects on the flight crew due to the '0' g environment. The brain experiences a tremendous fluid shift, which is responsible for many of the detrimental changes in physical behavior seen in astronauts. It therefore indicates that the brain may undergo major changes in its protein levels in a '0' g environment to counteract the stress. Analysis of these global changes in proteins may explain to better understand the functioning of brain in a '0' g condition. Toward such an effort, we have screened proteins in the hippocampus of mice kept in simulated microgravity environment for 7 days and have observed a few changes in major proteins as compared to control mice. Essentially, the results show a major loss of proteins in the hippocampus of mice subjected to simulated microgravity. These changes occur in structural proteins such as tubulin, coupled with the loss of proteins involved in metabolism. This preliminary investigation leads to an understanding of the alteration of proteins in the hippocampus in response to the microgravity environment.

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Citations

Aug 16, 2008·Experimental Brain Research·Antonio FrigeriDavid C Spray
May 14, 2008·Neurochemical Research·Poonam SarkarGovindarajan T Ramesh
Feb 19, 2011·Expert Review of Proteomics·Daniela GrimmSarah Baatout
Jun 6, 2009·Life Sciences·Poonam Sarkar, Barbara E Hayes
Oct 16, 2010·Cell Biology International·Gabriella TedeschiAngela Maria Rizzo
May 18, 2006·Physiological Genomics·Heather L NicholsXuejun Wen
Feb 9, 2018·Surgical Neurology International·Rahul JandialCharles L Limoli
Jun 23, 2019·International Journal of Molecular Sciences·Victoria GulimovaSergey Saveliev
Apr 7, 2016·NPJ Microgravity·Yoshiki TakamatsuMakoto Hashimoto
Mar 12, 2020·Scientific Reports·Wonjun NohSunggu Yang

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