Proteomic Analysis of One-carbon Metabolism-related Marker in Liver of Rat Offspring.

Molecular & Cellular Proteomics : MCP
Young-Ah YouYoung Ju Kim

Abstract

Maternal food intake has a significant effect on the fetal environment, and an inadequate maternal diet may result in intrauterine growth restriction. Intrauterine growth restriction newborn rat pups nursed by normal diet-fed dams exhibited rapid catch-up growth, which plays a critical role in the risk for metabolic and cardiovascular disease in later life. Specifically, one-carbon metabolism in the liver plays a critical role in placental and fetal growth. Impaired functioning of one-carbon metabolism is associated with increased homocysteine levels. In this study, we applied a comprehensive proteomic approach to identify differential expression of proteins related to one-carbon metabolism in the livers of rat offspring as an effect of maternal food restriction during gestation. Data are available via ProteomeXchange with identifier PXD002578. We determined that betaine-homocysteine S-methyltransferase 1, methylenetetrahydrofolate dehydrogenase 1, and ATP synthase subunit beta mitochondrial (ATP5B) expression levels were significantly reduced in the livers of rat offspring exposed to maternal food restriction during gestation compared with in the offspring of rats fed a normal diet (p < 0.05). Moreover, the expression levels o...Continue Reading

References

Jun 1, 1986·The Journal of Nutrition·J D FinkelsteinB J Harris
Sep 16, 1982·Biochemical and Biophysical Research Communications·J D FinkelsteinW E Kyle
May 1, 1997·Biological Reviews of the Cambridge Philosophical Society·M Desai, C N Hales
Mar 24, 1998·Annual Review of Medicine·H RefsumS E Vollset
Jun 11, 1998·European Journal of Obstetrics, Gynecology, and Reproductive Biology·K M Godfrey
Nov 11, 1999·Current Opinion in Lipidology·G T Gerhard, P B Duell
Aug 2, 2000·The American Journal of Clinical Nutrition·P M UelandS E Vollset
Apr 30, 2002·Placenta·Giorgio PardiIrene Cetin
May 11, 2002·The Proceedings of the Nutrition Society·William D Rees
May 15, 2002·The Journal of Biological Chemistry·Edward A Fisher, Henry N Ginsberg
May 20, 2003·Diabetic Medicine : a Journal of the British Diabetic Association·C A NewsomeC M Law
Aug 21, 2003·Clinical Chemistry·Marco Cattaneo
Apr 23, 2005·American Journal of Obstetrics and Gynecology·Michael G RossShengbiao Wang
Jan 26, 2006·Endocrine Reviews·Vanessa E MurphyVicki L Clifton
Apr 8, 2006·Journal of Inherited Metabolic Disease·R CastroI Tavares de Almeida
May 17, 2006·The Journal of Nutrition·William D ReesChristopher A Maloney
Jun 6, 2007·American Journal of Obstetrics and Gynecology·Mina DesaiMichael G Ross
Aug 19, 2007·The British Journal of Nutrition·Christopher J McNeilWilliam D Rees
Nov 27, 2008·The Journal of Biological Chemistry·Amanda J MacFarlanePatrick J Stover
Oct 9, 2009·The Journal of Nutrition·Patrick J Stover
Oct 17, 2009·Biochimica Et Biophysica Acta·M V MartinovF I Ataullakhanov
Oct 22, 2009·Hormone Research·Abigail L Fowden, Alison J Forhead
Apr 9, 2010·Current Opinion in Clinical Nutrition and Metabolic Care·Linda AttigClaudine Junien
Aug 4, 2010·International Journal of Obesity : Journal of the International Association for the Study of Obesity·H AingeK B Rooney
Dec 4, 2010·Antioxidants & Redox Signaling·Mesia M Steed, Suresh C Tyagi
Jun 4, 2011·Epigenetics : Official Journal of the DNA Methylation Society·Michael K Skinner
Feb 23, 2012·Journal of Nutrigenetics and Nutrigenomics·Patrick J Stover
Mar 16, 2012·Reviews in Endocrine & Metabolic Disorders·Satish C Kalhan, Susan E Marczewski
Jul 17, 2012·Journal of Proteome Research·Yoo-Jin ParkMyung-Geol Pang
Jan 19, 2013·The Journal of Maternal-fetal & Neonatal Medicine : the Official Journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians·Sangmi LeeYoung Ju Kim

❮ Previous
Next ❯

Citations

Dec 1, 2017·Obstetrics & Gynecology Science·Eun Jin Kwon, Young Ju Kim

❮ Previous
Next ❯

Datasets Mentioned

BETA
PXD002578

Methods Mentioned

BETA
electrophoresis
protein assay
enzyme-linked immunoassay

Software Mentioned

Mascot
PD Quest
PDQuest
Pathway Studio
SPSS

Related Concepts

Related Feeds

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

ATP Synthases

ATP synthases are enzymes located in the inner mitochondrial membrane that catalyze the synthesis of ATP during cellular respiration. Discover the latest research on ATP synthases here.

Related Papers

Ultrasound in Obstetrics & Gynecology : the Official Journal of the International Society of Ultrasound in Obstetrics and Gynecology
N BjarnegårdJ Brodszki
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Bérengère CoupéPatricia Parnet
American Journal of Physiology. Regulatory, Integrative and Comparative Physiology
Maria Z AlfaradhiSusan E Ozanne
© 2021 Meta ULC. All rights reserved