Proteomic analysis of schistosoma japonicum schistosomulum proteins that are differentially expressed among hosts differing in their susceptibility to the infection.

Molecular & Cellular Proteomics : MCP
Yang HongJiaojiao Lin

Abstract

Schistosomiasis is a tropical, parasitic disease affecting humans and several animal species. The aim of this study was to identify proteins involved in the growth and survival of the parasitic forms inside a host. Schistosomula of Schistosoma japonicum were isolated from three different hosts: the susceptible BALB/c mice; the Wistar rats, which have a considerably lower susceptibility; and the resistant reed vole, Microtus fortis. Soluble proteins of the schistosomula collected from the above three hosts 10 days postinfection were subjected to two-dimensional difference gel electrophoresis. Comparative proteomic analyses revealed that 39, 21, and 25 protein spots were significantly differentially expressed between schistosomula from mice and rats, mice and reed voles, or rats and reed voles, respectively (ANCOVA, p < 0.05). Further, the protein spots were identified by liquid chromatography-tandem MS. Bioinformatics analysis showed that the differentially expressed proteins were essentially those involved in the metabolism of proteins, ribonucleotides, or carbohydrates, or in stress response or cellular movement. This study represents the first attempt at profiling S. japonicum living in different states and provides a basis f...Continue Reading

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Citations

Aug 29, 2012·The Journal of Parasitology·Yang HongJiaojiao Lin
Feb 5, 2016·Molecular and Biochemical Parasitology·Hongxiao HanJiaojiao Lin
Jun 28, 2015·Experimental Parasitology·Anna M van der Ree, Francisca Mutapi
Mar 31, 2015·Molecular BioSystems·QingMing KongShaoHong Lu
Jun 10, 2020·International Journal of Molecular Sciences·Zhipeng XuHong You
Aug 23, 2019·Comparative Immunology, Microbiology and Infectious Diseases·Iman F Abou-El-NagaSalwa S Younis
Feb 11, 2021·Pathogens·Anna Zawistowska-DeniziakDaniel Młocicki
Aug 6, 2013·Journal of Proteome Research·Min ZhangJiaojiao Lin

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