Proteomic analysis of tegument-exposed proteins of female and male Schistosoma japonicum worms

Journal of Proteome Research
Min ZhangJiaojiao Lin

Abstract

The interplay between sexes is a prerequisite for female growth, reproductive maturation, and egg production, and the basis of schistosome pathopoiesis and propagation. The tegument is in direct contact with the host environment and its surface membranes are particularly crucial for schistosome survival in the definitive host. In this study, a streptavidin-biotin affinity purification technique combined with LC-MS/MS was used to analyze putative tegument-exposed proteins in female and male adult Schistosoma japonicum worms. In total, 179 proteins were identified in females and 300 in males, including 119 proteins common to both sexes, and 60 female biased and 181 male biased proteins. Some (e.g., serpin and CD36-like class B scavenger receptor) were involved in host-schistosome interactions, while some (e.g., gynecophoral canal protein) were important in the interplay between sexes. Gene Ontology analysis revealed that proteins involved in protein glycosylation and lysosome were highly expressed in females, while proteins involved in intracellular signal transduction, regulation of actin filament polymerization, and proteasome core complex were highly expressed in males. These results might elucidate physiological differences b...Continue Reading

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Citations

Sep 23, 2014·Acta Tropica·Patricia Placoná DinizElizabeth Angelica Leme Martins
Nov 13, 2015·Expert Review of Proteomics·Patrick DriguezGeoffrey N Gobert
Jun 6, 2015·Immunology and Cell Biology·Patrick DriguezDonald P McManus
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Mar 15, 2015·BMC Genomics·Nan HouQijun Chen
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Aug 21, 2015·PLoS Neglected Tropical Diseases·Chihiro TanigawaSatoshi Kaneko
Oct 11, 2015·Journal of Proteomics·Xiaodan CaoJiaojiao Lin
Jul 29, 2016·Molecular & Cellular Proteomics : MCP·Alessandra RavidàSandra M O'Neill
Dec 13, 2016·Expert Review of Proteomics·Javier SotilloAlex Loukas
May 29, 2020·Protoplasma·Miriam BischofsbergerMartina Sombetzki
Oct 30, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·David PirovichPatrick J Skelly
Sep 29, 2019·International Journal for Parasitology·Elżbieta Łopieńska-BiernatRobert Stryiński
Nov 13, 2021·International Journal for Parasitology·R Alan Wilson, Malcolm K Jones

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